The Cost of Extra Weight on Heart Failure Risk

This week, we investigate the links between heart failure and obesity. We explore what heart failure is, the risks, and how it can have long-term impacts on health. We also look into obesity, some of it's causes, and how it can contribute to heart failure risks. We also look at he two-way street between heart failure and obesty and how each can contribute to the other in a feedback loop, and what may be done to break it.References:Upadhyay, J., Farr, O., Perakakis, N., Ghaly, W., & Mantzoros, C. (2018). Obesity as a disease. Medical Clinics, 102(1), 13-33. https://www.medical.theclinics.com/article/S0025-7125(17)30128-1/abstractGroenewegen, A., Rutten, F. H., Mosterd, A., & Hoes, A. W. (2020). Epidemiology of heart failure. European journal of heart failure, 22(8), 1342-1356. https://onlinelibrary.wiley.com/doi/10.1002/ejhf.1858Alpert, M. A., Lavie, C. J., Agrawal, H., Aggarwal, K. B., & Kumar, S. A. (2014). Obesity and heart failure: epidemiology, pathophysiology, clinical manifestations, and management. Translational Research, 164(4), 345-356. https://www.sciencedirect.com/science/article/abs/pii/S1931524414001340Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W., Benjamin, E. J., Larson, M. G., ... & Vasan, R. S. (2002). Obesity and the risk of heart failure. New England Journal of Medicine, 347(5), 305-313. https://www.nejm.org/doi/full/10.1056/NEJMoa020245Horwich, T. B., Fonarow, G. C., & Clark, A. L. (2018). Obesity and the obesity paradox in heart failure. Progress in cardiovascular diseases, 61(2), 151-156. https://www.sciencedirect.com/science/article/pii/S0033062018300951?via=ihubEbong, I. A., Goff Jr, D. C., Rodriguez, C. J., Chen, H., & Bertoni, A. G. (2014). Mechanisms of heart failure in obesity. Obesity research & clinical practice, 8(6), e540-e548. https://www.sciencedirect.com/science/article/pii/S1871403X1300224XOreopoulos, A., Padwal, R., Kalantar-Zadeh, K., Fonarow, G. C., Norris, C. M., & McAlister, F. A. (2008). Body mass index and mortality in heart failure: a meta-analysis. American heart journal, 156(1), 13-22. https://www.sciencedirect.com/science/article/pii/S0002870308001543Mahajan, R., Stokes, M., Elliott, A., Munawar, D. A., Khokhar, K. B., Thiyagarajah, A., ... & Sanders, P. F(2020). Complex interaction of obesity, intentional weight loss and heart failure: a systematic review and meta-analysis. Heart, 106(1), 58-68. https://www.proquest.com/docview/23482079Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.comThank you for listening!