The current status of CAR-T therapy in CLL and challenges in this space

In recent years, novel immunotherapies, including CAR-T cell therapy, have greatly improved treatment options for patients with hematological malignancies. Although CAR-T cells have demonstrated remarkable success in several diseases, including multiple myeloma, acute lymphoblastic leukemia (ALL), and non-Hodgkin lymphoma (NHL), there has been less success with these agents in patients with chronic lymphocytic leukemia (CLL).  In this podcast, you will hear from John Gribben, MD, DSc, FRCP, FRCPath, FMed Sci, Barts Cancer Institute, London, UK, Marco Ruella, MD, University of Pennsylvania, Philadelphia, PA, and Adam Kittai, MD, Ohio State University, Columbus, OH, who share some insights into the current status of CAR-T therapy in CLL. The experts discuss challenges with developing efficacious CAR-T products for CLL, the possibility of combining CAR-T cells with ibrutinib, and further comment on the latest advances in CAR-T therapy for Richter's transformation.