The Dark Side of NMN Nobody Tells You About episode artwork

EPISODE · Mar 12, 2026 · 45 MIN

The Dark Side of NMN Nobody Tells You About

from Pushing The Limits · host Lisa Tamati

Is your NAD+ supplement actually working against you? Millions of people are taking NMN or NR thinking they're  doing something smart for their longevity. And the science  behind NAD+ is genuinely extraordinary. But the way most  people are supplementing it is incomplete — and there's  growing evidence it could be creating downstream harm most  people never connect back to their supplement. In this episode I break down the full NAD+ story — the  methylation trap, the CD38 drain, why high-dose NMN may be  elevating your cardiovascular risk markers, and what an  intelligent systems-level approach actually looks like. I co-developed NAD+ Next Gen with Peter Lehrke— and in this episode I walk  you through exactly why every ingredient is in the formula. WHAT WE COVER: - The 2023 Nature Cardiovascular Research findings on NMN & ADMA - How high-dose NMN drains your SAM pool and disrupts dopamine,    DNA methylation and homocysteine - CD38 — the biggest NAD+ drain in ageing nobody talks about - The bathtub model: precursors, drains, sirtuin efficiency - Why niacinamide may be smarter than high-dose NMN - EGCG, resveratrol, apigenin, quercetin, rutin — the why    behind each ingredient - 6 practical takeaways including which blood test to get now KEY LINKS: NAD+ Next Gen → https://aevumlabs.co.nz Rejuvenate Pro → https://shop.lisatamati.com Pushing The Limits community → https://www.lisatamati.com GET YOUR HOMOCYSTEINE TESTED: Optimal: below 7–8 µmol/L Above 10 µmol/L: address your methylation cycle urgently Lisa Tamati is a functional health practitioner, longevity  specialist, co-founder of Aevum Labs, host of Pushing The  Limits, and former elite ultra-endurance athlete with 25  years and 140+ ultramarathons across the world's most  extreme environments. Visit Lisa's website  www.lisatamati.com shop.lisatamati.com www.longlifehyperbarics.com www.aevumlabs.co.nz  www.Yourhealthcompass.org www.Myimmuneage.life  Work with Lisa:  

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The Dark Side of NMN Nobody Tells You About

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This episode was published on March 12, 2026.

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Is your NAD+ supplement actually working against you? Millions of people are taking NMN or NR thinking they're  doing something smart for their longevity. And the science  behind NAD+ is genuinely extraordinary. But the way most  people are...

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