The end of ads? AI agents are about to change how we buy episode artwork

EPISODE · Apr 27, 2026 · 57 MIN

The end of ads? AI agents are about to change how we buy

from a16z crypto show · host Andreessen Horowitz

Agents can now do almost anything a human can do with a computer. So what happens when they start spending money on your behalf? Sam Ragsdale (founder and CEO of Merit Systems, a startup building infrastructure for the agentic economy) joins a16z crypto's Eddy Lazzarin, Noah Levine, and Robert Hackett on the open agentic commerce stack, and why the internet's business model is about to get rewired. 00:00 – Intro  01:33 – Two flavors of agentic commerce  04:30 – What is an agent, actually?  12:57 – The headless merchant thesis  17:17 – What happens to existing friction?  24:45 – The economic contract of the web is broken  27:46 – Will agents get distracted by ads?  35:152– Stablecoins vs. credit cards  41:54 – Sam's bear case on interchange  49:11 – The killer app for agentic commerce   Sam Ragsdale on X: /samrags_  Eddy Lazzarin on X: /eddylazzarin  Noah Levine on X: /nlevine19  Robert Hackett on X: /rhackett    Follow a16z crypto: /a16zcrypto  Subscribe for more news and updates: a16zcrypto.substack.com Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Agents can now browse, decide, and buy on your behalf. So what happens to the internet's business model? Sam Ragsdale (founder & CEO of Merit Systems) joins a16z crypto's Eddy Lazzarin, Noah Levine, and Robert Hackett to unpack the open agentic commerce stack — from the headless merchant thesis to stablecoins vs. credit cards, and why the web's economic contract is quietly breaking.

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The end of ads? AI agents are about to change how we buy

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This episode is 57 minutes long.

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This episode was published on April 27, 2026.

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Agents can now do almost anything a human can do with a computer. So what happens when they start spending money on your behalf? Sam Ragsdale (founder and CEO of Merit Systems, a startup building infrastructure for the agentic economy) joins a16z...

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