The Epigenetic Equation

In this episode of the Dementia Researcher Podcast, guest host Dr Fiona McLean is joined by Dr Josh Harvey (University of Exeter), Dr Sarah Marzi (King’s College London - UK Dementia Research institute), Dr Alexi Nott (Imperial College London - UK Dementia Research institute), and Dr Sam Washer (Wellcome Trust Sanger Institute) to discuss the role of epigenetics in Alzheimer’s and dementia research. The episode offers a broad exploration of epigenetics in neurodegenerative diseases, highlighting how gene regulation beyond DNA sequences is advancing our understanding of Alzheimer’s and related conditions. It covers the impact of environmental and lifestyle factors on disease development, as well as emerging research techniques and technologies that could inform future diagnostic and therapeutic approaches. Key Topics: The fundamentals of epigenetics and its distinction from traditional genetics. How epigenetic research is shaping our understanding of Alzheimer's disease. The role of environmental factors in influencing epigenetic changes. New technologies and their application in epigenetic studies. The potential for epigenetics in developing future diagnostics and therapies for neurodegenerative diseases. -- A transcript of this show, links and show notes and profile on all our guests are available on our website at https://www.dementiaresearcher.nihr.ac.uk. If you prefer to watch rather than listen, you will find a video version of this podcast on Apple Podcasts, YouTube, and on our website. Leave us a tip: https://dementia-researcher.captivate.fm/support Follow us on social media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://www.twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social Download and Register with our Community App: https://www.onelink.to/dementiaresearcher We gratefully acknowledge the support of our funders: Alzheimer’s Association, Race Against Dementia, Alzheimer’s Research UK, Alzheimer’s Society, and the National Institute for Health and Care Research. The views and opinions expressed by guests in this podcast are their own and do not necessarily reflect those of the producers, funders, or sponsors. Subscribe to our sister show 'Dementia Researcher The Blogs': https://podfollow.com/dementia-researcher-blogs