The Gold Standard Loop Diuretic for HFrEF

Furosemide is the most prescribed loop diuretic for heart failure; however, furosemide’s pharmacokinetic parameters are less than ideal compared to other loop diuretics. Join host, Geoff Wall, as he evaluates the first randomized controlled trial comparing loop diuretics in heart failure.The GameChangerTorsemide has potential pharmacokinetic advantages compared to furosemide in the treatment of heart failure. However, a recent study did not find meaningful differences in clinical outcomes when comparing loop diuretics for the treatment of heart failure.Show Segments00:00 - Introduction01:00 - Current Loop Diuretic Use02:21 - Furosemide vs Torsemide Pharmacokinetics04:58 - Looking at the TRANSFORM-HF Study14:54 - The GameChanger: TRANSFORM-HF Outcomes19:16 - Connecting to Practice: Picking Between the Two21:52 - Closing RemarksHostGeoff Wall, PharmD, BCPS, FCCP, CGPProfessor of Pharmacy Practice, Drake UniversityInternal Medicine/Critical Care, UnityPoint HealthReferences and ResourcesEffect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial. Redeem your CPE hereCPE (Pharmacist)Get a membership & earn CE for GameChangers Podcast episodes (30 mins/episode)Pharmacists: Get a membershipCE InformationLearning ObjectivesUpon successful completion of this knowledge-based activity, participants should be able to:1. List the pharmacokinetic differences between furosemide and torsemide2. Discuss the findings of the Mentz et al study evaluating loop diuretics0.05 CEU/0.5 HrUAN: 0107-0000-23-101-H01-PInitial release date: 02/27/2023Expiration date: 02/27/2024Additional CPE and CME details can be found here.Follow CEimpact on Social Media:LinkedInInstagram