EPISODE · Jan 26, 2026 · 23 MIN
The Hijacked Brain: Why Willpower Fails in Addiction | Ep 74
from No-Nonsense Psychiatry Practical Mental Health Lets Talk Together · host markjohnskay
Addiction is the "survival drive" gone rogue. In this episode of No Nonsense Psychiatry, we look at how substances co-opt the Midbrain, convince the brain that the drug is more important than food, water, or sex. We explore the Prefrontal-Limbic Disconnect—the biological reason why a person can "know" a behavior is destructive but feel powerless to stop it. We provide three actionable insights into the neurobiology of craving and how to rebuild the "Top-Down" control of the Prefrontal Cortex.
What this episode covers
Addiction is the "survival drive" gone rogue. In this episode of No Nonsense Psychiatry, we look at how substances co-opt the Midbrain, convince the brain that the drug is more important than food, water, or sex. We explore the Prefrontal-Limbic Disconnect—the biological reason why a person can "know" a behavior is destructive but feel powerless to stop it. We provide three actionable insights into the neurobiology of craving and how to rebuild the "Top-Down" control of the Prefrontal Cortex.
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The Hijacked Brain: Why Willpower Fails in Addiction | Ep 74
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