EPISODE · Aug 22, 2026 · 1H
The Home Security System in the Lipid Neighborhood with Dr. Josh Wageman
from Uncle Jimmy's Podcast · host Jimmy leary
In this episode, Jimmy sits down with Dr. Josh Wageman, a physical therapist, PhD researcher, lipid specialist, pastor, and former Ivy League track athlete, to break down cholesterol, heart disease, and dementia in plain English. The conversation focuses on how to think about ApoB particles, CAC scoring, LP little a, inflammation, and statins without the usual confusion or scare tactics.Dr. Wageman shares why cholesterol education matters, how his own path into lipid science started with a frustrating article he could barely understand, and why he built his book around metaphors that patients can actually use. The result is a practical and deeply human discussion about prevention, context, and taking ownership of your health.Key topicsDr. Josh Wageman’s background spanning physical therapy, endocrinology, youth ministry, coaching, and lipidologyWhy cholesterol became his focus after realizing how little the basics were explained clearlyThe connection between cholesterol disturbances, heart disease, and Alzheimer's diseaseThe "home security system in the lipid neighborhood" framework for understanding cardiovascular riskWhy ApoB-containing particles, especially LDL, matter more than the simple label of "bad cholesterol"Why CAC scoring can reveal plaque even when a standard lipid panel looks normalThe role of LP little a as a major inherited risk factor that should be checked at least onceHow inflammation, HSCRP, and IL6 fit into cardiovascular risk and what high inflammation may actually meanA nuanced look at statins, including benefits, limitations, muscle side effects, and when combination therapy may make more senseThe importance of individual context over population-level risk calculatorsAction Items Ask your doctor whether a CAC score makes sense for you, especially in midlife or with family historyAsk about LP little a testing at least once if you have not had it checkedReview your full lipid picture, not just total cholesterol and HDLUse inflammation markers like HSCRP and IL6 in context, not in isolationRevisit your care plan with a clinician who is willing to explain the why, not just the whatGo purchase Josh book https://a.co/d/00WKG6PoGet in touch with Dr. Josh https://share.google/Aq6c8EL3gDYYagVQB
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