The Ketamine Effect - Dr. Les Cole

In this episode of MindBody Matters, host and Psychotherapist Greg Rennie talks with Dr. Les Cole, psychotherapist and author of The Ketamine Effect. Drawing on data from over 1,000 clients who have received ketamine-assisted therapy, Dr. Cole explains how this medicine can help people struggling with depression, anxiety, PTSD, and other mental health challenges. He explores the neuroscience of ketamine — how it promotes neuroplasticity, emotional release, and deep healing when paired with psychotherapy. Dr. Cole also opens up about his own transformative experience with ketamine, describing how it shifted his perspective as both a clinician and a person. Together, Greg and Dr. Cole discuss safety, preparation, and integration — emphasizing that while ketamine can open a window for profound change, true healing happens through ongoing therapeutic work.