The metabolite problem: for 5 of the top 20 ingredients, the gut bacteria are the real pharmacist

Curcumin -> tetrahydrocurcumin. Ellagitannins (pomegranate) -> urolithins. Ginsenosides -> Compound K. Resveratrol -> dihydroresveratrol. Bacosides -> jujubogenin. In each case, the gut metabolite may be more potent than the parent compound. This means the same ingredient is a different medicine in different people, depending on their microbiome. Personalized nutrition isn't about genetics, it's about bacteria.Publications of interest:https://pubmed.ncbi.nlm.nih.gov/27274718/https://pubmed.ncbi.nlm.nih.gov/35118817/https://pubmed.ncbi.nlm.nih.gov/30669635/