EPISODE · Aug 27, 2025 · 1H 48M
The most important century (with Holden Karnofsky)
from Clearer Thinking with Spencer Greenberg · host Spencer Greenberg
Read the full transcript here. Has society reached ‘peak progress’? Can we sustain the level of economic growth that technology has enabled over the last century? Have researchers plucked the last of science's "low-hanging fruit?" Why did early science innovators have outsized impact per capita? As fields mature, why does per-researcher output fall? Can a swarm of AI systems materially accelerate research? What does exponential growth hide about the risk of collapse? Will specialized AI outcompete human polymaths? Is quality of life still improving - and how confident are we in those measures? Is it too late to steer away from the attention economy? Can our control over intelligent systems scale as we develop their power? Will AI ever be capable of truly understanding human values? And if we reach that point, will it choose to align itself? Holden Karnofsky is a Member of Technical Staff at Anthropic, where he focuses on the design of the company's Responsible Scaling Policy and other aspects of preparing for the possibility of highly advanced AI systems in the future. Prior to his work with Anthropic, Holden led several high-impact organizations as the co-founder and co-executive director of charity evaluator GiveWell, and one of three Managing Directors of grantmaking organization Open Philanthropy. You can read more about ideas that matter to Holden at his blog Cold Takes. Further reading: Holden's "most important century" series Responsible scaling policies Holden's thoughts on sustained growth Staff Spencer Greenberg — Host / Director Josh Castle — Producer Ryan Kessler — Audio Engineer Uri Bram — Factotum WeAmplify — Transcriptionists Igor Scaldini — Marketing Consultant Music Broke for Free Josh Woodward Lee Rosevere Quiet Music for Tiny Robots wowamusic zapsplat.com Affiliates Clearer Thinking GuidedTrack Mind Ease Positly UpLift [Read more]
What this episode covers
Read the full transcript here. • Has society reached ‘peak progress’? Can we sustain the level of economic growth that technology has enabled over the last century? Have researchers plucked the last of science's "low-hanging fruit?" Why did early science innovators have outsized impact per capita? As fields mature, why does per-researcher output fall? Can a swarm of AI systems materially accelerate research? What does exponential growth hide about the risk of collapse? Will specialized AI outcompete human polymaths? Is quality of life still improving - and how confident are we in those measures? Is it too late to steer away from the attention economy? Can our control over intelligent systems scale as we develop their power? Will AI ever be capable of truly understanding human values? And if we reach that point, will it choose to align itself? • Holden Karnofsky is a Member of Technical Staff at Anthropic, where he focuses on the design of the company's Responsible Scaling Policy and other aspects of preparing for the possibility of highly advanced AI systems in the future. Prior to his work with Anthropic, Holden led several high-impact organizations as the co-founder and co-executive director of charity evaluator GiveWell, and one of three Managing Directors of grantmaking organization Open Philanthropy. You can read more about ideas that matter to Holden at his blog Cold Takes (https://www.cold-takes.com/author/holden/). • Further reading: • Holden's "most important century" series (https://www.cold-takes.com/most-important-century/) • Responsible scaling policies (https://forum.effectivealtruism.org/posts/ntWikwczfSi8AJMg3/we-re-not-ready-thoughts-on-pausing-and-responsible-scaling) • Holden's thoughts on sustained growth (https://www.lesswrong.com/posts/5FZxhdi6hZp8QwK7k/this-can-t-go-on) • Staff • Spencer Greenberg (https://www.spencergreenberg.com/) — Host / Director • Josh Castle (mailto:[email protected]) — Producer • Ryan Kessler (https://tone.support/) — Audio Engineer • Uri Bram (https://uribram.com/) — Factotum • WeAmplify (https://www.weamplify.info/) — Transcriptionists • Igor Scaldini (https://www.linkedin.com/in/igorscaldini/) — Marketing Consultant • Music • Broke for Free (https://freemusicarchive.org/music/Broke_For_Free/Something_EP/Broke_For_Free_-_Something_EP_-_05_Something_Elated) • Josh Woodward (https://www.joshwoodward.com/song/AlreadyThere) • Lee Rosevere (https://archive.org/details/MusicForPodcasts04/Lee+Rosevere+-+Music+for+Podcasts+4+-+11+Keeping+Stuff+Together.flac) • Quiet Music for Tiny Robots (https://www.freemusicarchive.org/music/Quiet_Music_for_Tiny_Robots/The_February_Album/05_Tiny_Robot_Armies) • wowamusic (https://gamesounds.xyz/?dir=wowamusic) • zapsplat.com (https://www.zapsplat.com/music/summer-haze-slow-chill-out-house-track-with-a-modern-pop-feel-warm-piano-chords-underpin-the-track-with-warm-pads-and-a-repetitive-synth-arpeggio/) • Affiliates • Clearer Thinking (https://www.clearerthinking.org/) • GuidedTrack (https://guidedtrack.com/) • Mind Ease (https://mindease.io/) • Positly (https://positly.com/) • UpLift (https://www.uplift.app/)
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The most important century (with Holden Karnofsky)
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