The Multi-Omics Series Part 3: CYP1B1 and Estrogen Detoxification

Multi-omics is the layering of genetic information (genomics) with laboratory biomarker results (metabolomics) to understand the root cause of disease and risk. This educational series focuses on genetic variants in specific enzymes and explains how to evaluate the systemic effects. Today’s episode is a discussion of the cytochrome P450 enzyme CYP1B1. This enzyme is important in hormone detoxification. Genetic variants (single nucleotide polymorphisms or SNPs) in CYP1B1 might predispose a patient for risk regarding many hormonally mediated diseases, though this is not always the case. Listen to find out more about the enzyme pathways used in estrogen detoxification, what to look for when deciding if a genetic variant in CYP1B1 is expressed, and learn what you can do to about it. “Some SNPs result in an enzyme that works faster (upregulation). Some SNPs result in an enzyme that works slower (downregulation).” – Michael Chapman, ND Today on The Lab Report: 2:30 Cytochrome P450 enzymes and CYP1B1 2:55 Review of general Phase I and Phase II detoxification 7:00 Basics of estrogen detoxification pathways and where CYP1B1 works 9:00 What does a SNP in CYB1B1 do? 11:45 What profiles and biomarkers are helpful to assess expression of a CYPB1B1 SNP? 17:00 How do we support patients with a CYP1B1 SNP? 21:05 Question of the day: “What is the difference between FMV and 24hour Complete Hormones?” Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: [email protected]. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and show not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.