The NAD+ Equation: Science, Stress, and the Promise of Supplementation

What exactly is NAD+ and why is it suddenly everywhere—from supplement bottles to anti-aging headlines? In this episode of Supplement Source, Jeff Ventura sits down with Dr. Andrew Shao, SVP of Global Scientific and Regulatory Affairs at Niagen Bioscience, to demystify the science behind NAD+, its precursors, and why your cells might need a boost. From the impact of stress and aging to the fine line between marketing hype and scientific evidence, this candid conversation cuts through the acronyms and buzzwords to explore what we really know—and what we still don’t—about optimizing cellular health through supplementation. About the Council for Responsible Nutrition (CRN)  The Council for Responsible Nutrition (CRN), founded in 1973 and based in Washington, D.C., is the leading trade association representing the dietary supplement and functional food industry. Bringing together manufacturers, ingredient suppliers, and service providers, CRN unites its member companies around a shared commitment to science, transparency, and responsible business practices—advancing a strong, credible marketplace that supports consumer health and industry growth.In an increasingly complex regulatory and media environment, CRN serves as the industry’s front line—shaping science-based policy, defending market access, and countering misinformation. Through strategic advocacy, self-regulatory leadership, voluntary guidelines, and evidence-based communications, CRN ensures that responsible companies are recognized, protected, and positioned to innovate and compete. Learn more at crnusa.org and follow @CRN_Supplements on X and LinkedIn.