EPISODE · Jul 6, 2026 · 14 MIN
The Original Weight Loss Meds: Phentermine, Qsymia, and Contrave
from Modern Metabolic Health with Dr. Lindsay Ogle, MD · host Lindsay Ogle, MD
GLP-1 medications are everywhere right now, but the “older” obesity medications never stopped helping real patients and they can still be the right tool when matched well. I walk through the three FDA-approved first-generation obesity management options and how I think about using them safely in modern obesity medicine, especially when cost, access, or specific symptoms like cravings are part of the story.We start with phentermine, the original FDA-approved weight loss medication, and get practical about what it actually does: appetite suppression, typical stimulant-like side effects, morning dosing, expected weight loss, and the key reasons it may be unsafe (like uncontrolled high blood pressure, certain heart conditions, glaucoma, or uncontrolled hyperthyroidism). Then we move into Qsymia, the phentermine plus topiramate combination, including why it tends to produce more weight loss, what to know about pricing, and the topiramate-specific risks like teratogenicity, kidney stones, fatigue, taste changes, and tingling sensations.Next, we dig into Contrave (bupropion plus naltrexone) and why it can be a great fit when food cravings, emotional eating, mood symptoms, or goals like cutting back on alcohol or smoking are front and center. I also explain the non-negotiable safety rules: no history of seizures, and no opioids of any kind, including products like kratom or 7OH, due to the risk of precipitated withdrawal. We close by talking strategy, including combining these oral options with GLP-1 therapy, using them for maintenance, and an honorable mention of metformin for insulin resistance and metabolic health.Subscribe, share this with someone who needs clear guidance, and leave a review so more people can find the podcast and improve their metabolic health.-------------------------------------------------Qsymia discount programContrave discount program👩🏼⚕️ Live in Missouri? Want to be my patient?Telehealth clinic: https://missourimetabolichealth.com🥑 Have questions you want answered on the podcast? Email [email protected]✨Freebies✨Anti-Obesity Medication OptionsHow To Prevent DiabetesHealthy Habits WorkbookPreventative Health Checklist🤗 Socials:Instagram: https://www.instagram.com/dr.lindsayogle/TikTok: https://www.tiktok.com/@dr..lindsay.ogle?_t=8prC4VUQZ5i&_r=1YouTube: https://www.youtube.com/channel/UCMV0X6U0JLZgRMiNwGtmpeg
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GLP-1 medications are everywhere right now, but the “older” obesity medications never stopped helping real patients and they can still be the right tool when matched well. I walk through the three FDA-approved first-generation obesity management options and how I think about using them safely in modern obesity medicine, especially when cost, access, or specific symptoms like cravings are part of the story. We start with phentermine, the original FDA-approved weight loss medication, and get p...
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The Original Weight Loss Meds: Phentermine, Qsymia, and Contrave
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