The Physiologic Roots of Panic - A Holistic Approach

EPISODE · Jan 31, 2026 · 29 MIN

The Physiologic Roots of Panic - A Holistic Approach

from Holistic Psychiatry Podcast · host Courtney Snyder MD

In this episode, I discuss panic attacks and underlying vulnerabilities that can increase the sensitivity of our alarm system. * What is a panic attack and what does it feel like? * What neurotransmitters are involved?* What is panic disorder?* What nutritional, genetic, and hormonal factors can be at play?* What types of inflammation and toxicity can lead to panic attacks?* How do the immune, limbic and autonomic nervous system contribute?* How does insecure attachment, trauma and stress interact with these other vulnerabilities?Takeaways* Panic attacks occur when the brain’s alarm system is overly sensitive.* Physical symptoms of panic attacks can be debilitating and terrifying.* Underlying physiological factors contribute to vulnerability to panic attacks.* Neurotransmitters like norepinephrine and GABA play crucial roles in panic disorders.* Hormonal imbalances, especially in women, can increase the likelihood of panic attacks.* Mast cells are involved in the immune response and can trigger panic symptoms.* Biotoxins, such as mold toxins, can contribute to mast cell activation, limbic system dysfunction and autonomic nervous system dysfunction* Limbic system dysfunction can lead to heightened anxiety and panic.* The autonomic nervous system regulates our fight or flight response.* Emotional stressors and trauma can contribute to panic attacks, but appear to be aligning with other physiologic vulnerabilitiesChapters00:00 Understanding Panic Attacks03:07 Physiological Factors Behind Panic Attacks06:00 Neurotransmitters, Nutrient Levels and Panic Disorder08:52 The Role of Genetic Variants & Hormones in Panic Attacks12:07 Inflammation and Panic Attacks14:53 Mast Cells - The Bridge Between the Immune & Central Nervous Systems18:06 Biotoxins and Their Impact on Panic21:00 Limbic System Dysfunction and Panic24:11 The Autonomic Nervous System’s Role26:45 Emotional Stressors and Panic AttacksAs always, I welcome any comments and questions. Your interests and what you care about helps guide the information I share. Also, its really nice for me to be in conversation and learning from you.Until next time,CourtneyTo learn more about my discovery calls, non-patient consultations, or mentoring, please visit my website at:CourtneySnyderMD.comMedical Disclaimer:This newsletter is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment for either yourself or others, including but not limited to patients that you are treating (if you are a practitioner). Consult your physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe

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