The Real Causes of Alzheimer's Disease with Dr. Craig Tanio: Rational Wellness Podcast 456

The Real Causes of Alzheimer's Disease with Dr. Craig Tanio: Rational Wellness Podcast 456 Podcast Highlights The Real Causes of Alzheimer's Disease with Dr. Craig Tanio: Rational Wellness Podcast 456 Dr. Craig Tanio on Precision Functional Medicine for Cognitive Decline: Infections, Toxins, Biomarkers, and Genetics Dr. Ben Weitz introduces the Rational Wellness Podcast and interviews Dr. Craig Tanio about a systems-based, precision medicine approach to preventing and treating mild cognitive impairment and early Alzheimer's, contrasting it with amyloid-only drug strategies. Tanio describes his background and work implementing and studying Dale Bredesen's network-insufficiency paradigm, including participation in a multi-center randomized clinical trial with clinician judgment, standardized labs, lifestyle essentials, and variable neuromodulatory therapies. They discuss common drivers such as chronic infections (COVID-related immune effects, viral reactivation, tick-borne illness) and toxicants (especially mold/mycotoxins), emphasizing "low and slow" detox and the risk of over-detoxing. Tanio highlights biomarkers (PTau217, NFL, GFAP), EEG/QEEG as a "stethoscope for the brain," HRV, genomics (BCHE, DIO2, TCN2), hormones, diet flexibility, and supplements including plasmalogens, high-dose thiamine injections, and low-dose lithium affecting tau/amyloid markers. 00:00 Show Intro and Mission 01:02 Guest and Alzheimer's Paradigm Shift 03:48 Dr Tanyo's Journey to Systems Care 05:51 Why One Change Isn't Enough 07:34 Randomized Trial Overview 09:39 Precision Approach vs Protocol 13:36 Common Drivers Infections and Toxins 15:17 Chronic Infections and Viral Reactivation 19:41 Biomarkers and Clinical Judgment 22:37 Toxins Mold and Detox Pace 27:26 Low and Slow Detox Strategy 29:55 Measuring Progress EEG and HRV 33:11 Sponsor Apollo Wearable Break 34:44 Expanded Testing Genomics and Genie 36:41 Fatty Acids Omega 9 and Plasmalogens 39:34 Fatty Acid Supplements 40:56 Genetics and Biomarkers 44:53 Hormone Therapy Debate 49:24 Diet Approaches Compared 50:47 Supplements That Move Needle 58:05 Peptides and Protocol Tuning 01:00:55 Alzheimer's Drugs Reality Check 01:04:31 Registry and Coverage Push 01:09:53 Research Next Steps 01:13:43 Practice Info and Wrap   Dr. Craig Tanio is one of the physicians involved in implementing and studying this systems-based approach and participated in a recent randomized clinical trial evaluating this protocol for patients with mild cognitive impairment and early Alzheimer's disease. Dr. Tanio is a co-founder of Rezilir Health and the website is rezilirhealth.com.   Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure. Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calli