The Rising Burden of Kidney Stones: Evolution and Mechanisms of Kidney Stone Disease

What causes kidney stones to form, and why are they becoming increasingly common? In Part 1, David S. Goldfarb explores the physiological mechanisms behind kidney stone disease, the evolving roles of diet, metabolism, and hydration, and the links between kidney stones and broader metabolic conditions, including metabolic syndrome and fatty liver disease. He also reflects on how advances in research have transformed our understanding of risk factors, genetics, and disease prevention.