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EPISODE · Nov 20, 2025 · 35 MIN

The Science Behind Autism and Medications

from Charting Pediatrics

Recently, leucovorin and acetaminophen have been at the center of new discussions in pediatric medicine. Could leucovorin really help some children with autism? Does the latest evidence suggest acetaminophen has any impact on neurodevelopment? In today's episode, we'll break down what the science actually tells us, what remains uncertain and how pediatricians can confidently guide families through these complex topics. Joining us for this important discussion is Abigail Angulo, MD. She is a developmental-behavioral pediatrician at Children's Hospital Colorado. She is also an associate professor at the University of Colorado School of Medicine. Some highlights from this episode include:  The science behind autism  The role of Tylenol in pregnancy and newborn development  What leucovorin is used for and when it should be prescribed  How to navigate difficult conversations with families who expect certain outcomes For more information on Children's Colorado, visit: childrenscolorado.org. 

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