The Science on Kratom: Kratom Journal Club (Bonus with CME)

* Link to get CME at the bottom of the show notes *Ever wondered if a plant could be both a herbal remedy and a controversial subject in addiction medicine? Join us as we uncover the multifaceted nature of Kratom with Dr. Sonia Del Tredici and Dr. John Keenan from the Addiction Medicine Journal Club podcast for a journal club style episode on Kratom. Together, we explore Kratom's historical uses for pain relief and fatigue management and its growing popularity as an aid in opioid withdrawal. This episode promises to give you a thorough understanding of its pharmacological effects, including interactions with opioid receptors and anti-inflammatory benefits.Our conversation shifts to the intriguing trends in Kratom usage across the United States. We dissect three recent studies on Kratom, highlighting Kratom's allure as a perceived safer option for managing anxiety, depression, and pain. Despite its benefits, we don't shy away from discussing its potential for addiction and the demographic reach of its users. This episode challenges listeners to consider whether the overlap between Kratom users and those with other substance use disorders is surprising or expected, urging healthcare providers to adopt open-ended dialogues to address patient needs effectively.In a deep dive into Kratom Use Disorder, our discussion includes a fascinating case series study examining the use of buprenorphine for treatment. We highlight the study's findings on withdrawal management and Kratom metabolite reduction, exploring the effectiveness of buprenorphine in stabilizing patients. With a significant portion of patients remaining in follow-up care, we ponder the subjective effects of using Kratom alongside buprenorphine. Tune in to grasp the complexities of Kratom use and the importance of education and ongoing research, as we prepare for an upcoming interview with an industry professional to continue this enlightening series.Our episode reviews three studies on Kratom to facilitate our discussion. Here are those studies:Smith KE, Dunn KE, Rogers JM, Grundmann O, McCurdy CR, Garcia-Romeu A, Schriefer D, Swogger MT, Epstein DH. Kratom use as more than a "self-treatment". Am J Drug Alcohol Abuse. 2022 Nov 2;48(6):684-694.  Hill K, Grundmann O, Smith KE, Stanciu CN. Prevalence of Kratom Use Disorder Among Kratom Consumers. J Addict Med. 2024 May-Jun 01;18(3):306-312. Broyan, V. R., Brar, J. K., Allgaier, Student, T., & Allgaier, J. T. (2022). Long-term buprenorphine treatment for kratom use disorder: A case series. Substance Abuse, 43(1), 763–766. To contact Dr. Grover: [email protected] this link to get CME for this episode:https://micaresed.org/courses/podcast-addiction-medicine-journal-club/