The Shot #1: Ibogaine — From Schedule I to the Oval Office

A presidential signature, a Joe Rogan text, and a plant-based psychedelic that's been quietly transforming addiction treatment outside U.S. borders for decades. In this episode of The Shot, Tara breaks down what ibogaine actually is, what the early research on PTSD and opioid use disorder really shows, why cardiac risk has kept it off American soil — and what Trump's new executive order means for the future of psychedelic medicine. NEWS SOURCES White House Fact Sheet — Trump Executive Order on Psychedelics (April 2026): https://www.whitehouse.gov/fact-sheets/2026/04/fact-sheet-president-donald-j-trump-is-accelerating-medical-treatments-for-serious-mental-illness/ Scientific American — Trump's Order on Psychedelics: Far-Reaching Science Consequences: https://www.scientificamerican.com/article/trumps-order-on-psychedelics-could-have-far-reaching-science-consequences/ NPR — Trump Signs Order Fast-Tracking Psychedelic Drug Review: https://www.npr.org/2026/04/18/nx-s1-5789859/psychedelic-treatments-mental-health Al Jazeera — Trump Joined by Joe Rogan as He Signs Order to Speed Up Psychedelic Review: https://www.aljazeera.com/news/2026/4/18/trump-joined-by-joe-rogan-as-he-signs-order-to-speed-up-psychedelic-review The Hill — Joe Rogan, Donald Trump Executive Order on Psychedelic Drug Research: https://thehill.com/homenews/administration/5837641-joe-rogan-donald-trump-executive-order-psychadelic-drug-research-mental-health/ Fox News — Joe Rogan Reveals Text to Trump That Helped Expedite Psychedelics Review: https://www.foxnews.com/media/joe-rogan-reveals-text-trump-helped-expedite-federal-review-psychedelics CNBC — Trump Signs Order to Speed Review of Psychedelics Including Ibogaine: https://www.cnbc.com/2026/04/18/trump-executive-order-psychedelic-drugs-ibogaine.html CLINICAL & RESEARCH SOURCES Nature Medicine (2024) — Magnesium-Ibogaine Therapy in Veterans With Traumatic Brain Injuries (Cherian et al.): https://www.nature.com/articles/s41591-023-02705-w Journal of Substance Abuse Treatment (2022) — Systematic Literature Review of Clinical Trials of Ibogaine (Köck et al.): https://doi.org/10.1016/j.jsat.2021.108717 Current Neuropharmacology (2023) — Ibogaine/Noribogaine in the Treatment of Substance Use Disorders (Mosca et al.): https://doi.org/10.2174/1570159X21666221017085612 Psychopharmacology (2022) — Adverse Events of Ibogaine in Humans: Updated Systematic Review (Ona et al.): https://doi.org/10.1007/s00213-021-05964-y American Journal of Therapeutics (2024) — Psychedelic Therapy Primer: Ibogaine (Cherian et al.): https://doi.org/10.1097/MJT.0000000000001723 Pharmacological Research (2023) — Ibogaine: A Legacy Within the Current Renaissance of Psychedelic Therapy (Mash DC): https://doi.org/10.1016/j.phrs.2022.106620 Addiction (2022) — Safety of Ibogaine Administration in Detoxification of Opioid-Dependent Individuals (Knuijver et al.): https://doi.org/10.1111/add.15448 Addiction (2026) — Ibogaine and Cardiovascular Complications: Prolonged QT Interval and Ventricular Arrhythmias (Brunt TM): https://doi.org/10.1111/add.70319 Journal of Psychoactive Drugs (2025) — Cross-Sectional Insights Into Ibogaine Clinical Trials (Swieczkowski et al.): https://doi.org/10.1080/02791072.2025.2491385 JACS (2025) — Deciphering Ibogaine's Matrix Pharmacology (Hwu et al.): https://doi.org/10.1021/jacs.5c06325 Substance Use & Misuse (2025) — Ibogaine: Revisiting an Ancient Alkaloid for Modern Opioid Dependence (Moore et al.): https://doi.org/10.1080/10826084.2025.2604213 Episodes every Monday ⭐️ Subscribe, Rate and Review! 🍸 Recipes drop on socials Discounts: 15% off Comfrt apparel Purple Carrot: 40% off your first box ClassPass: 2 weeks free 15% off non-alcoholic spirits at The Zero Proof 💳 Support us on Patreon | ☕️ Buy Me a Coffee Contains affiliate links. We may earn a commission at no additional cost to you.