EPISODE · Oct 22, 2025 · 1H 3M
The Underpinnings of Aging and What to Do About It
from Peptides and Longevity: Redefining Aging and Transforming Health with Dr. Kent Holtorf · host Kent Holtorf, MD
The secret to living better for longer starts with removing the cells that make you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver pulls back the curtain on senolytics, showing how to clear senescent cells and build you back up with mitochondria, hormones, and targeted peptides.Want to age in reverse? Start by clearing out the cells making you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver reframes longevity around one simple idea, which is that you remove what ages you and then rebuild what keeps you young. He explains how senescent cells accumulate, why they become inflammatory factories, and how fasting and senolytics can clear the backlog. He then shows how to protect and upgrade mitochondria, why telomeres work as a useful marker rather than a destiny, and where peptides belong. The result is a stepwise, precision plan that starts with clearance, moves into cellular energy, and finishes with targeted repair for brain, skin, hair, and whole-body performance. Watch the full episode now and learn how to start clearing the cells that make you old.Dr. Joseph Cleaver is a board-certified internist and fellow in anti-aging and metabolic medicine who blends preventive lifestyle medicine, regenerative therapeutics, and peptide science. He teaches clinicians nationwide and sees patients through the Paradigm Wellness Medical Group. He also hosts small-group masterminds on longevity and regenerative medicine at his winery in Sonoma.Dr. Joseph CleaverWebsite: www.pwmgmed.comIntegrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalkshttps://drtalks.com/podcast-service/
What this episode covers
The secret to living better for longer starts with removing the cells that make you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver pulls back the curtain on senolytics, showing how to clear senescent cells and build you back up with mitochondria, hormones, and targeted peptides.Want to age in reverse? Start by clearing out the cells making you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver reframes longevity around one simple idea, which is that you remove what ages you and then rebuild what keeps you young. He explains how senescent cells accumulate, why they become inflammatory factories, and how fasting and senolytics can clear the backlog. He then shows how to protect and upgrade mitochondria, why telomeres work as a useful marker rather than a destiny, and where peptides belong. The result is a stepwise, precision plan that starts with clearance, moves into cellular energy, and finishes with targeted repair for brain, skin, hair, and whole-body performance. Watch the full episode now and learn how to start clearing the cells that make you old.Dr. Joseph Cleaver is a board-certified internist and fellow in anti-aging and metabolic medicine who blends preventive lifestyle medicine, regenerative therapeutics, and peptide science. He teaches clinicians nationwide and sees patients through the Paradigm Wellness Medical Group. He also hosts small-group masterminds on longevity and regenerative medicine at his winery in Sonoma.Dr. Joseph CleaverWebsite: www.pwmgmed.comIntegrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalkshttps://drtalks.com/podcast-service/
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The Underpinnings of Aging and What to Do About It
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