Tinnitus Treatments Result From Clinical Trials

This week we explore tinnitus, a condition marked by ringing in the ears. Tinnitus is affects roughly 10% of Americans and remains poorly understood. Unfortunately, this poor understanding means there are no disease-modifying treatments available. Luckily, clinical researchers have been hard at work looking for relief for tinnitus sufferers, and there are some symptomatic treatments. Listen in to find out what tinnitus is, risks and complications, and some ways you may be able to find relief.References:Bhatt, J. M., Lin, H. W., & Bhattacharyya, N. (2016). Prevalence, severity, exposures, and treatment patterns of tinnitus in the United States. JAMA Otolaryngology–Head & Neck Surgery, 142(10), 959-965. https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2533660Shargorodsky, J., Curhan, G. C., & Farwell, W. R. (2010). Prevalence and characteristics of tinnitus among US adults. The American journal of medicine, 123(8), 711-718. https://pubmed.ncbi.nlm.nih.gov/30073285/Makar, S. K. (2021). Etiology and pathophysiology of tinnitus: a systematic review. The International Tinnitus Journal, 25(1), 76-86. https://www.tinnitusjournal.com/articles/etiology-and-pathophysiology-of-tinnitus--a-systematic-review-16383.htmlDalrymple, S. N., Lewis, S. H., & Philman, S. (2021). Tinnitus: diagnosis and management. American family physician, 103(11), 663-671. https://www.aafp.org/pubs/afp/issues/2021/0601/p663.htmlShore, S. E., & Wu, C. (2019). Mechanisms of noise-induced tinnitus: insights from cellular studies. Neuron, 103(1), 8-20. https://www.cell.com/neuron/fulltext/S0896-6273(19)30433-7Staecker, H., Morelock, M., Kramer, T., Chrbolka, P., Ahn, J. H., & Meyer, T. (2017). Safety of repeated-dose intratympanic injections with AM-101 in acute inner ear tinnitus. Otolaryngology–Head and Neck Surgery, 157(3), 478-487. https://pubmed.ncbi.nlm.nih.gov/28608739/National Library of Medicine. (n.d.). ClinicalTrials.gov. U.S.Department of Health and Human Services. [Website. Accessed 24 March, 2024]. https://clinicaltrials.gov/search?cond=Tinnitus&aggFilters=results:with,status:com&locStr=United%20States&country=United%20StatesBeukes, E. W., Andersson, G., & Manchaiah, V. (2021). Patient uptake, experiences, and process evaluation of a randomized controlled trial of internet-based cognitive behavioral therapy for tinnitus in the United States. Frontiers in medicine, 8, 771646. https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.771646/fullConlon, B., Hamilton, C., Meade, E., Leong, S. L., O Connor, C., Langguth, B., ... & Lim, H. H. (2022). Different bimodal neuromodulation settings reduce tinnitus symptoms in a large randomized trial. Scientific reports, 12(1), 1-18. https://www.nature.com/articles/s41598-022-13875-xShare with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.comThank you for listening!