tPA (Deep Dive R29)
from EM Clerkship Hosted by Zack Olson, MD and Michael Estephan, MD
tPA usage is controversial. Listen to find out why. Read more to form your own opinions. Episode Sources: After Re-Analysis, No Trials Show Efficacy of tPA in Acute Ischemic Stroke Clinical Policy: Use of Intravenous Tissue Plasminogen Activator for the Management of Acute Ischemic Stroke in the Emergency Department Why we can’t trust clinical guidelines – BMJ Alteplase for Stroke: Money and Optimistic Claims Buttress the “Brain Attack” Campaign Tissue Plasminogen Activator (tPA) for Acute Ischemic Stroke: Net benefits and harms unclear due to uncertainty in data – the NNT
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