Trainwreck

The rewrite today is for Trainwreck. The deep dive is about drug-drug interactions between alcohol and antibiotics. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode Fact versus Fiction: a Review of the Evidence behind Alcohol and Antibiotic Interactions https://pubmed.ncbi.nlm.nih.gov/31871085/ Doxycycline PK after whiskey or wine https://pubmed.ncbi.nlm.nih.gov/7113712/ Doxycycline + rifampin for Brucellosis infection in rats fed alcohol https://pubmed.ncbi.nlm.nih.gov/16323439/ Doxycycline + rifampin PK changes in human Brucellosis infections https://www.ncbi.nlm.nih.gov/pmc/articles/PMC188288/ Long-term alcohol consumption and half-life of erythromycin and doxycycline https://pubmed.ncbi.nlm.nih.gov/1002368/ Tyramine concentrations in alcohol https://pubmed.ncbi.nlm.nih.gov/28824206/, https://pubmed.ncbi.nlm.nih.gov/34655830/ Linezolid and tyramine and increase in SBP https://pubmed.ncbi.nlm.nih.gov/11361052/ Cephalosporin induced disulfiram-like reaction: a retrospective review of 78 cases. https://pubmed.ncbi.nlm.nih.gov/24670024/ Cephalosporin induced hypoprothrombinemia due to side chains of N-methylthiotetrazole (latamoxef, cefmenoxime, cefoperazone, cefotetan, cefamandole) https://pubmed.ncbi.nlm.nih.gov/3350995/ Metronidazole plus alcohol in rats https://pubmed.ncbi.nlm.nih.gov/10798595/ RCT metronidazole plus alcohol in humans https://pubmed.ncbi.nlm.nih.gov/12022894/ Retro case-control of pts admitted after ethanol who received metronidazole https://pubmed.ncbi.nlm.nih.gov/37494646/ Z-drugs adverse reactions https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077048/ Zolpidem plus alcohol and ICU admission https://pubmed.ncbi.nlm.nih.gov/20458214/