Treating postpartum depression with psychedelics? Why researchers say it may be effective episode artwork

EPISODE · Jul 17, 2026 · 8 MIN

Treating postpartum depression with psychedelics? Why researchers say it may be effective

from In The NOCO · host KUNC

Nearly one in five new moms experiences anxiety or depression during pregnancy or after giving birth. These conditions can lead to difficulty bonding with a newborn, or a higher risk of suicide, if left untreated.   But a new experimental treatment is giving some researchers hope. It's a psychoactive substance derived from mushrooms called luvesilocin. In a recent set of FDA trials, a single dose of luvesilocin turned out to be highly effective – and worked more quickly – in improving patients' postpartum depression and anxiety.  Dr. Camille Hoffman is an OB-GYN and Professor of Maternal Fetal Medicine at the University of Colorado Anschutz. She helped oversee an early clinical study of luvesilocin, and wrote about it for The Conversation.  Hoffman spoke with Erin O'Toole about what researchers found, and why luvesilocin may be a promising alternative to psychotherapy or prescription drugs that are often used to treat postpartum depression. * * * * *Sign up for the In The NoCo newsletter: Visit KUNC.org Questions? Feedback? Story ideas? Email us: [email protected] Like what you're hearing? Help more people discover In The NoCo by rating the show on your favorite podcast app. Thanks!  Host and Producer: Erin O'Toole Executive Producer: Brad Turner  Theme music by Robbie Reverb Additional music by Blue Dot Sessions In The NoCo is a production of KUNC News and Community Radio for Northern Colorado.

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