TRT Dosing: Minimum Effective Dose vs Maximum Tolerable Dose, with Dr. Andrew Winge

What this episode covers

Healthspan Podcast | Episode 3TRT Dosing: Minimum Effective Dose vs Maximum Tolerable Dose, with Dr. Andrew WingeHow much testosterone is enough? How much is too little?And at what point are you no longer doing replacement therapy… ?In this episode of the Healthspan Podcast, I sit down with Dr. Andrew Winge of Man Medicine to discuss one of the most debated topics in testosterone replacement therapy:Minimum Effective Dose vs Maximum Tolerable Dose.We break down what realistic dosing looks like, why free testosterone is more important than total, the significance of SHBG, insulin resistance, the significance of genetic variability, anabolic resistance, aromatization, estrogen myths, body composition as a key metric, metabolic health, and why the “right” TRT dose is highly individual.We also discuss why many men fail TRT despite “normal” lab values, the limitations of current guidelines, why symptom resolution matters, and the growing divide between conservative TRT philosophy and the increasingly common “TRT+” approach seen online and in some clinics.If you’re on TRT, considering it, or trying to optimize your protocol, this episode will help you think about dosing in a much more nuanced and individualized way.⏱️ Timestamps00:00 Why “Safe” TRT Often Fails Men00:18 Introduction to Dr. Andrew Winge01:34 Dr. Winge’s Personal TRT Story05:40 How Testosterone Changed His Medical Practice08:46 Why Most Providers Don’t Understand TRT and why you shouldn't expect them to11:44 The Problem With Modern Primary Care13:35 Why Muscle Mass Matters for Longevity18:20 Minimum Effective Dose vs Maximum Tolerable Dose19:18 Why TRT Guidelines Fail Many Men21:57 Why Many Men Quit Testosterone Therapy26:06 Free Testosterone vs Total Testosterone28:45 Why Some Men Need Higher Testosterone Levels31:49 Why Out-of-Range Labs Aren’t Automatically Dangerous35:04 Testosterone Safety and Higher Dose Studies38:19 Testosterone, Muscle Mass, and Metabolic Health40:42 When Higher Testosterone Doses Stop Helping41:23 Why Lifestyle Still Matters on TRT43:35 Optimal Free Testosterone Ranges45:20 Why Broader Medical Experience Matters in a TRT provider46:47 The Big Rocks of Health Still Matter Most49:03 Estradiol, Aromatization, and Obesity51:20 Why Estradiol Is Protective in Men56:31 Why Adiposity Is the Real Problem57:58 The Problem With Aromatase Inhibitors59:01 DIM, Estrogen Myths, and Bad TRT Advice01:02:12 The Business Side of TRT Clinics01:05:12 Why Estradiol Labs Often Mislead Doctors01:07:18 Estradiol, Nitric Oxide, and Erectile Function🎙️ Guest: Dr. Andrew Winge | Man MedicineWebsitehttps://www.manmedicine.com/Instagramhttps://www.instagram.com/manmedicinemd/YouTubehttps://www.youtube.com/@manmedicine📌 Need expert HRT guidance?At Men’s Healthspan, we fix hormones and metabolic health so you can feel better, look better, and live better.➡️ Book your free consult here:https://MensHealthspan.com📩 Newsletter + Free Diet Templates👉 https://subscribepage.io/mpnLInYou’ll get occasional emails with real-world tips on HRT, diet, training, and improving healthspan — from a healthcare provider who practices what he prescribes.🔢 Free TRT ToolsFree Testosterone Calculatorhttps://menshealthspan.com/free-testosterone-calculator-2/Testosterone Dosage Calculatorhttps://menshealthspan.com/testosterone-dosage-calculator-use-insulin-syringes-for-trt/GLP-1 Dose Calculatorhttps://menshealthspan.com/semaglutide-and-tirzepatide-dose-calculator/

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