Turning Up the Heat on Weight Loss

In this week's episode, we explore some of the roles receptors play in the body. We focus on Cannabanoid 1 (CB1) receptors, which regulate appetite and energy expenditure in the body, but can have effects in the brain as well. We look at how receptors can do different things depending on location and that the challenge of medications is in targeting right receptors in the right place.References:Crater GD, Lalonde K, Ravenelle F, Harvey M, Després JP. Effects of CB1R inverse agonist, INV‐202, in patients with features of metabolic syndrome. A randomized, placebo‐controlled, double‐blind phase 1b study. Diabetes, Obesity and Metabolism. 2024 Feb;26(2):642-9. https://doi.org/10.1111/dom.15353Berg KA, Clarke WP. Making sense of pharmacology: inverse agonism and functional selectivity. International Journal of Neuropsychopharmacology. 2018 Oct;21(10):962-77. https://doi.org/10.1093/ijnp/pyy071Cinar R, Iyer MR, Kunos G. The therapeutic potential of second and third generation CB1R antagonists. Pharmacology & therapeutics. 2020 Apr 1;208:107477. https://doi.org/10.1016/j.pharmthera.2020.107477Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.comThank you for listening!