Types of Bias in Clinical Research & Impact on Results episode artwork

EPISODE · Apr 10, 2026 · 25 MIN

Types of Bias in Clinical Research & Impact on Results

from This Is Why with Dr. Busti · host Anthony Busti, MD, PharmD, MSc, FNLA, FAHA

Types of bias in research and their impact on results are critical to understanding study design, internal validity, and clinical decision-making. In this lecture on This Is Why, Dr. Busti walks through how bias is introduced, how it affects results, and how clinicians should interpret it.This lecture is part of the This Is Why evidence-based medicine (EBM) series, designed to help clinicians connect research methodology to real-world practice.Topics Covered:- Equation of error: truth, bias, and random error- Internal validity and critical appraisal- Selection bias and sampling bias- Confounding and lead-time bias- Recall bias and observer bias- Loss to follow-up and procedure bias- Differential vs non-differential misclassification- Study design hierarchy and risk of bias- Publication bias and clinical trial registries- Why bias control changes effect size👉 Access bonus materials and downloads from this episode at: https://www.thisiswhy.health/topics/types-bias-clinical-research-design-methodology👉 Get more with a free membership at https://www.thisiswhy.health/- Access free downloads from our videos - Access deep dive content from Dr. Busti- Organize content via playlists & collections- Join live Q&A- Receive member newsletters- Coupons & discounts for exam prep resources👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content.🔔 Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more!#bias in research #study design #internal validity #evidence based medicine #Dr BustiDisclaimer:This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

Episode metadata supplied by the publisher feed · Published Apr 10, 2026

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Types of bias in research and their impact on results are critical to understanding study design, internal validity, and clinical decision-making. In this lecture on This Is Why, Dr. Busti walks through how bias is introduced, how it affects results, and how clinicians should interpret it. This lecture is part of the This Is Why evidence-based medicine (EBM) series, designed to help clinicians connect research methodology to real-world practice. Topics Covered: - Equation of error: truth,...

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