Understanding Tumor Evolution in Osteosarcoma

Osteosarcoma Webinar Series: Chelsey Burke, MD, a physician-scientist from Memorial Sloan Kettering Cancer Center and an OutSmarting Osteosarcoma Young Investigator 2024 grant recipient, shares findings from her work studying the evolution of osteosarcoma tumors. At present, we have a limited understanding of how osteosarcoma tumors change with conventional treatment and go on to develop drug resistance. Dr. Burke discusses the use of mouse models to investigate osteosarcoma tumor evolution and identify emerging resistance mechanisms that can be therapeutically targeted.Chelsey Burke, MD is an assistant attending and young investigator at Memorial Sloan Kettering Cancer Center. After graduating from the University of Iowa with a B.S. in biology, Dr. Burke obtained her medical degree from St. George’s University School of Medicine. Following pediatric residency at Advocate Children’s Hospital in Chicago, where she served as pediatric chief resident, she joined the combined Memorial Sloan Kettering and New York Presbyterian-Weill Cornell pediatric hematology and oncology fellowship program. During fellowship, Dr. Burke joined the laboratory of Dr. Filemon Dela Cruz and Dr. Andrew Kung where her research focuses on pediatric cancer modeling and preclinical drug development. Dr. Burke has a particular interest in bone sarcomas, including osteosarcoma, and is involved in the preclinical evaluation of several novel therapeutics. She hopes this work can be translated into early phase clinical trials and, ultimately, improve outcomes for children, adolescents, and young adults with high-risk sarcomas.