EPISODE · Jul 17, 2026 · 8 MIN
Understanding Zonulin: The Gut Hormone Key to Sustainable Weight Loss
from CFP Weight Loss with Russell Clark · host Russell Clark, FNP-C
Understanding Zonulin: The Gut Hormone Key to Sustainable Weight Loss Welcome to CFP Weight Loss. I'm Russell Clark, Nurse Practitioner. Today, we're exploring Understanding Zonulin: The Gut Hormone Key to Sustainable Weight Loss. ... Take a breath, settle in, and let's walk through this together — clearly, calmly, and based on what the evidence actually shows. ... We'll touch on Zonulin, Leaky Gut, GLP-1 GIP — especially as they apply to real people over forty. ... Zonulin has emerged as a critical player in the complex relationship between gut health, inflammation, and metabolic function. Often called the “gatekeeper” of intestinal permeability, zonulin regulates how tightly the cells of your gut lining are bound together. When zonulin levels rise, the tight junctions loosen, allowing larger particles to pass into the bloodstream. This increased permeability triggers systemic inflammation that directly sabotages weight-loss efforts. ... Modern metabolic science shows that elevated zonulin disrupts leptin sensitivity, impairs mitochondrial efficiency , and promotes insulin resistance. Understanding and managing zonulin may be the missing link for those who struggle with stubborn weight despite calorie control. Listen at CFP Weight Loss — clinical guide with Russell Clark, FNP-C. Read more: https://blog.cfpweightloss.com/understanding-understanding-zonulin-for-weight-loss
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