Unlocking Antibody Development with AI with Dr. Pin-Kuang Lai

In this episode of BioTalk Unzipped, hosts Gregory Austin and Dr. Chad Briscoe interview Asst. Professor Pin-Kuang Lai from Stevens Institute of Technology about his keynote speech at AAPS NBC 2025 and the intersection of AI and molecular engineering, particularly in predicting the viscosity of monoclonal antibodies. They discuss the challenges of high concentration formulations, the importance of AI validation, and the future of formulation development. Lai shares insights from his international research journey and collaborations with pharmaceutical companies, as well as opportunities for students interested in this field.00:00 Preview & Intro01:58 Deep Viscosity and AI in Antibody Development04:39 AI Validation and Model Reliability07:12 International Journey and Collaborative Research08:42 Future of Formulation Development10:30 AAPS NBC Experience11:30 Academic vs. Industry Career Paths12:31 Collaboration with Pharmaceutical Companies13:59 Modeling Protein Aggregation Challenges14:43 Student Engagement and Research Opportunities15:45 Expanding Applications of Machine LearningDr. Pin-Kuang Laihttps://www.linkedin.com/in/pin-kuang-lai/Stevens Institute of Technology - https://www.stevens.edu/Dr. Lai’s Publications - https://www.linkedin.com/in/pin-kuang-lai/details/publications/The DeepViscosity Model - https://devpred.onrender.com/DeepViscosityDr. Chad Briscoehttps://www.linkedin.com/in/chadbriscoe/Celerion - https://www.celerion.com/Gregory Austinhttps://www.linkedin.com/in/gregoryaustin1/Celerion - https://www.celerion.com/