Vaccination in Tuberculosis

BCG has long been the only widely used vaccination strategy since it's initial use over 100 years ago. In high TB burden settings it is still recommended in children to protect against disseminated disease though the lasting protection offered by BCG vaccination has been poor at best.Today, Emeritus Professor Warwick Britton AO FAHMS from the Centenary Institute and the University of Sydney speaks with Professor Greg Fox about how the BCG vaccine works and where it's utility lies. Professor Britton also explores exciting research in tuberculosis vaccines and what developments may be required to control tuberculosis in the future.REFERENCES:Hart, D'Arcy, and Sutherland. "BCG and vole bacillus vaccines in the prevention of tuberculosis in adolescence and early adult life." Br Med J 2.6082 (1977): 293-295.Nemes, Elisa, et al. "Prevention of M. tuberculosis infection with H4: IC31 vaccine or BCG revaccination." New England Journal of Medicine 379.2 (2018): 138-149. Darrah, Patricia, et al. "Prevention of tuberculosis in macaques after intravenous BCG immunization." Nature 577.7788 (2020): 95-102.