Vascular Pathogenesis in Long COVID

Send us Fan MailKruger A, Joffe DJ, Lloyd-Jones G, et al. Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook. Semin Thromb Hemost. 2024; https://doi.org/10.1055/s-0044-1790603 https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0044-1790603.pdf@DavidJoffe64 @PutrinoLab @SalamonSMD @resiapretorius @ArneauxK  This article examines the role of vascular dysfunction in both acute and long COVID, proposing that persistent thrombotic endothelialitis is a key driver of long-term symptoms. The authors review the scientific evidence for widespread endothelial dysfunction leading to chronic symptomatology, explore potential therapeutic interventions, and highlight the need for early intervention to prevent long-term vascular and cellular dysfunction. The article also explores the potential role of viral persistence and oral dysbiosis in ongoing endothelial inflammation in Long COVID.   NOT YET RECRUITINGLumbrokinase for Long Covid Clinical TrialClinicalTrials.gov ID NCT06511050Sponsor Icahn School of Medicine at Mount SinaiInformation provided by David Putrino, Icahn School of Medicine at Mount Sinai (Responsible Party)Last Update Posted 2024-08-09https://clinicaltrials.gov/study/NCT06511050?cond=Long%20COVID%20&intr=Lumbrokinase&rank=1This is Heliox: Where Evidence Meets EmpathyIndependent, moderated, timely, deep, gentle, clinical, global, and community conversations about things that matter.  Breathe Easy, we go deep and lightly surface the big ideas. Support the showDisclosure: This podcast uses AI-generated synthetic voices for a material portion of the audio content, in line with Apple Podcasts guidelines. We make rigorous science accessible, accurate, and unforgettable.Produced by Michelle Bruecker and Scott Bleackley, it features reviews of emerging research and ideas from leading thinkers, curated under our creative direction with AI assistance for voice, imagery, and composition. Systemic voices and illustrative images of people are representative tools, not depictions of specific individuals.We dive deep into peer-reviewed research, pre-prints, and major scientific works—then bring them to life through the stories of the researchers themselves. Complex ideas become clear. Obscure discoveries become conversation starters. And you walk away understanding not just what scientists discovered, but why it matters and how they got there.Independent, moderated, timely, deep, gentle, clinical, global, and community conversations about things that matter.  Breathe Easy, we go deep and lightly surface the big ideas.Spoken word, short and sweet, with rhythm and a catchy beat.http://tinyurl.com/stonefolksongs