What a Cold War Hero Can Teach Us About Chronic Hives

On this week's episode, we explore the ins and outs of chronic spontaneous urticaria. We discuss the signs, symptoms, complications, and how-it-works of the disease, including how linchpin molecules in the cell like Bruton's tyrosine kinase may be the key to tempering extreme reposnses from a hair-trigger immune system.References:Isachenkov, V. (2017, September 19). Stanislav Petrov, who averted nuclear war, dies at 77. The Associated Press. https://apnews.com/general-news-b9de4e3c9a5949e4a27e8ea601059f25Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al (2022) The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy; 77:734-6. https://onlinelibrary.wiley.com/doi/full/10.1111/all.15090Gonçalo, M., Gimenéz‐Arnau, A., Al‐Ahmad, M., Ben‐Shoshan, M., Bernstein, J. A., Ensina, L. F., ... & Maurer, M. (2021). The global burden of chronic urticaria for the patient and society. British Journal of Dermatology, 184(2), 226-236. https://doi.org/10.1111/bjd.19561Jain V, Giménez-Arnau A, Hayama K, et al (2024) Remibrutinib demonstrates favorable safety profile and sustained efficacy in chronic spontaneous urticaria over 52 weeks. J Allergy Clin Immunol; 153(2):479-86 https://doi.org/10.1016/j.jaci.2023.10.007Balp, M.M., Halliday, A.C., Severin, T, et al (2022). Clinical remission of chronic spontaneous urticaria (CSU): A Targeted Literature Review. Dermatol Ther (Heidelb). Jan;12(1):15-27. https://link.springer.com/article/10.1007/s13555-021-00641-6Saini SS, Kaplan AP (2018) Chronic Spontaneous Urticaria: The Devil's Itch. J Allergy Clin Immunol Pract; 6(4):1097-106. https://doi.org/10.1016/j.jaip.2018.04.013Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.comThank you for listening!