EPISODE · Aug 25, 2026 · 8 MIN
What Is De Novo Lipogenesis (DNL)? The Hidden Driver of Metabolic Health
from CFP Weight Loss with Russell Clark · host Russell Clark, FNP-C
What Is De Novo Lipogenesis (DNL)? The Hidden Driver of Metabolic Health Welcome to CFP Weight Loss. I'm Russell Clark, Nurse Practitioner. Today, we're exploring What Is De Novo Lipogenesis (DNL)? The Hidden Driver of Metabolic Health. ... We'll take this one layer at a time, with a cool head and a focus on published research rather than internet folklore. ... We'll touch on De Novo Lipogenesis, Metabolic Reset, Tirzepatide Protocol — especially as they apply to real people over forty. ... De novo lipogenesis (DNL) . is the metabolic process where your body converts excess carbohydrates into fat. While this pathway has existed for millennia as a survival mechanism, modern diets high in refined sugars have turned DNL into a primary driver of obesity, insulin resistance, and metabolic dysfunction. ... Understanding DNL reveals why the old Calories In Calories Out (Calories In, Calories Out) . model falls short. Hormones, not just calories, dictate whether incoming energy gets burned or stored as fat. When DNL is chronically elevated, the body prioritizes fat creation over fat burning, creating a cycle that's difficult to break without targeted intervention. ... First — how de novo lipogenesis actually works. ... Listen at CFP Weight Loss — clinical guide with Russell Clark, FNP-C. Read more: https://blog.cfpweightloss.com/bfly-whatis-de-novo-lipogenesis-dnl
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