When antidepressants don’t work + Faith leaders' warning to PM episode artwork

EPISODE · Jan 16, 2026 · 15 MIN

When antidepressants don’t work + Faith leaders' warning to PM

from The Briefing · host LiSTNR

20% of Aussies with depression don't respond positively to antidepressant medication.  In this episode of The Briefing, Natarsha Belling is joined by Co-Director of Health and Policy at The University of Sydney's Brain and Mind Centre, Professor Ian Hickie, who explains why antidepressants work well for many people — and fail badly for others. Drawing on new Australian research, involving more than 15,000 Australians, Professor Hickie unpacks the evidence that shows depression is not one condition, but many, each with distinct biological drivers. Headlines: Some of Australia’s most prominent religious leaders have urged the government to halt their hate speech reforms, Venezuela’s opposition leader has presented her Nobel Peace Prize to US President Donald Trump, and the mother of one of Elon Musk’s fourteen children is suing X.  Follow The Briefing: TikTok: @thebriefingpodInstagram: @thebriefingpodcast YouTube: @TheBriefingPodcastSee omnystudio.com/listener for privacy information.

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When antidepressants don’t work + Faith leaders' warning to PM

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This episode was published on January 16, 2026.

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20% of Aussies with depression don't respond positively to antidepressant medication.  In this episode of The Briefing, Natarsha Belling is joined by Co-Director of Health and Policy at The University of Sydney's Brain and Mind Centre, Professor Ian...

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