EPISODE · Jun 3, 2026 · 49 MIN
When Neurodevelopmental Symptoms Start in the Womb
from Demystifying PANS/PANDAS Podcast · host Nancy O'Hara MD
What if a child's neuroinflammation began long before the first symptoms appeared? In this episode of Demystifying PANS/PANDAS, Dr. Somer DelSignore joins us to speak about congenital vector-borne infections and how in utero exposure to pathogens and maternal immune activation may influence brain development, immune programming, and later neuropsychiatric or developmental challenges.They explore why pregnancy timing matters, which early signs may raise suspicion, why negative testing does not always rule out transmission, and how hidden infectious burdens can sit beneath labels like PANS, autism, or autoimmune encephalopathy. Dr. DelSignore also shares the thinking behind her RESET Protocol and why lasting recovery often requires addressing inflammation, infections, gut health, toxins, detoxification, and nervous system support together.- - - - -About the Guest:Dr. Somer DelSignore, DNP, BC-PNP, FMAPS, ILADS, FAAOT is a board-certified child and adolescent provider known for her expertise in diagnosing and managing complex chronic illness in children. She is the CEO and founder of Hudson Valley Integrative Health and has developed the RESET Protocol, a root-cause framework designed to address immune dysfunction systematically.She is a fellow at MAPS and AAOT, a member of ILADS, and has deep experience in autoimmune and neuroimmune conditions, along with the psychiatric manifestations of infectious disease, especially tick-borne infections. Dr. DelSignore earned her Master of Nursing Practice from the University of Pennsylvania and her Doctor of Nursing Practice from SUNY Upstate Medical University, and completed residencies at CHOP, Penn State, and Children's Health in Dallas.- - - - -Hopewell is a family-owned pharmacy which has been in existence since 1987. You can call them at800-792-6670, email them at [email protected] or visit them online at www.hopewellrx.com.Hopewell Pharmacy: Your partner in integrative wellness.Other Links for the Guest:Website: https://hudsonvalleyintegrativehealth.com/LinkedIn: https://www.linkedin.com/in/somerdelsignorekidslyme/- - - - -Nancy O’Hara, MD, MPH, FAAP, FMAPSWebsite: https://www.drohara.comFacebook: https://www.facebook.com/drnancyohara/Instagram: https://www.instagram.com/nhoharamd/LinkedIn: https://www.linkedin.com/in/nancy-o-hara-md-mph-faap-390781258/Join our listeners on Spotify, Apple Podcasts, and iHeart Radio.- - - - -PODCASTThank you for listening.Please subscribe and share.This podcast is produced by DrTalks.comhttps://drtalks.com/podcast-service/
What this episode covers
What if a child's neuroinflammation began long before the first symptoms appeared? In this episode of Demystifying PANS/PANDAS, Dr. Somer DelSignore joins us to speak about congenital vector-borne infections and how in utero exposure to pathogens and maternal immune activation may influence brain development, immune programming, and later neuropsychiatric or developmental challenges.They explore why pregnancy timing matters, which early signs may raise suspicion, why negative testing does not always rule out transmission, and how hidden infectious burdens can sit beneath labels like PANS, autism, or autoimmune encephalopathy. Dr. DelSignore also shares the thinking behind her RESET Protocol and why lasting recovery often requires addressing inflammation, infections, gut health, toxins, detoxification, and nervous system support together.- - - - -About the Guest:Dr. Somer DelSignore, DNP, BC-PNP, FMAPS, ILADS, FAAOT is a board-certified child and adolescent provider known for her expertise in diagnosing and managing complex chronic illness in children. She is the CEO and founder of Hudson Valley Integrative Health and has developed the RESET Protocol, a root-cause framework designed to address immune dysfunction systematically.She is a fellow at MAPS and AAOT, a member of ILADS, and has deep experience in autoimmune and neuroimmune conditions, along with the psychiatric manifestations of infectious disease, especially tick-borne infections. Dr. DelSignore earned her Master of Nursing Practice from the University of Pennsylvania and her Doctor of Nursing Practice from SUNY Upstate Medical University, and completed residencies at CHOP, Penn State, and Children's Health in Dallas.- - - - -Hopewell is a family-owned pharmacy which has been in existence since 1987. You can call them at800-792-6670, email them at [email protected] or visit them online at www.hopewellrx.com.Hopewell Pharmacy: Your partner in integrative wellness.Other Links for the Guest:Website: https://hudsonvalleyintegrativehealth.com/LinkedIn: https://www.linkedin.com/in/somerdelsignorekidslyme/- - - - -Nancy O’Hara, MD, MPH, FAAP, FMAPSWebsite: https://www.drohara.comFacebook: https://www.facebook.com/drnancyohara/Instagram: https://www.instagram.com/nhoharamd/LinkedIn: https://www.linkedin.com/in/nancy-o-hara-md-mph-faap-390781258/Join our listeners on Spotify, Apple Podcasts, and iHeart Radio.- - - - -PODCASTThank you for listening.Please subscribe and share.This podcast is produced by DrTalks.comhttps://drtalks.com/podcast-service/
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When Neurodevelopmental Symptoms Start in the Womb
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