Why 400+ Alzheimer's Drugs Failed (Here's What Works) episode artwork

EPISODE · Oct 5, 2025 · 1H 30M

Why 400+ Alzheimer's Drugs Failed (Here's What Works)

from The Optispan Podcast with Matt Kaeberlein · host Optispan

Alzheimer’s is often talked about but rarely understood in full. For decades, most research has focused on amyloid plaques, but what if that’s only part of the story? In this deep-dive, Dr. Cory, from the Institute for Systems Biology explains a new way of looking at Alzheimer’s: It is not simply a plaque problem, but as a breakdown in the brain’s “debris management” system, especially how it handles cholesterol. This perspective connects the dots between genes like ApoE4, the role of microglia, and everyday factors like sleep and stress. It also helps explain why current drugs give mixed results, and what might actually work in the future. Dr. Cory also shares practical insights on prevention and what a new era of treatment could look like .This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here: www.onebillionmedia.comIf you want to understand where the future of Alzheimer’s prevention and treatment is headed, watch this podcast now!

Alzheimer’s is often talked about but rarely understood in full. For decades, most research has focused on amyloid plaques, but what if that’s only part of the story? In this deep-dive, Dr. Cory, from the Institute for Systems Biology explains a new way of looking at Alzheimer’s: It is not simply a plaque problem, but as a breakdown in the brain’s “debris management” system, especially how it handles cholesterol. This perspective connects the dots between genes like ApoE4, the role of microglia, and everyday factors like sleep and stress. It also helps explain why current drugs give mixed results, and what might actually work in the future. Dr. Cory also shares practical insights on prevention and what a new era of treatment could look like .This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here: www.onebillionmedia.comIf you want to understand where the future of Alzheimer’s prevention and treatment is headed, watch this podcast now!

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Why 400+ Alzheimer's Drugs Failed (Here's What Works)

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How long is this episode of The Optispan Podcast with Matt Kaeberlein?

This episode is 1 hour and 30 minutes long.

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This episode was published on October 5, 2025.

What is this episode about?

Alzheimer’s is often talked about but rarely understood in full. For decades, most research has focused on amyloid plaques, but what if that’s only part of the story? In this deep-dive, Dr. Cory, from the Institute for Systems Biology explains a new...

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