Why I start patients on semaglutide, not tirzepatide episode artwork

EPISODE · May 18, 2026 · 6 MIN

Why I start patients on semaglutide, not tirzepatide

from Better Off with Victoria Reynolds

Tirzepatide has stronger trial data. So why does Victoria start most patients on semaglutide first? In today's episode she explains the sequencing strategy that keeps your most powerful tool in reserve — and why starting at the ceiling leaves you with nowhere to go when you plateau.Hear the full protocol breakdown on Episode 1 of the main Better Off podcast. Follow Better Off Daily for a new tip every weekday.📘 Better Off: The GLP-1 Protocol — A Prescriber's Complete Guide to Ozempic, Wegovy, Mounjaro & Zepbound — betteroff.com/books — Amazon link coming soon 💉 GLP-1 protocol guide: rx.betteroff.com/guide 🥤 Protein for GLP-1 patients: rx.betteroff.com/protein 📱 Instagram: @betteroffwellnessI'm a nurse practitioner and I own a weight loss clinic. This podcast is education — not medical advice. Nothing here replaces a conversation with your own provider.

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Why I start patients on semaglutide, not tirzepatide

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