Why Imaging Misses Chronic Pain: Structural vs Physiologic Thinking (Part 2) episode artwork

EPISODE · Jan 11, 2026 · 35 MIN

Why Imaging Misses Chronic Pain: Structural vs Physiologic Thinking (Part 2)

from The Modern Pain Podcast · host Mark Kargela

Part 2 goes from definitions to implications.Bottom-up pain does not mean “it’s in the tissues.”This episode is a recording of a live interview with pain researcher and clinician Asaf Weissman. If you haven’t watched Part 1, start there—we laid the foundation: why pain semantics matter, how mixed messages harm patients, and why “nothing is wrong with your body” is an overreach.In Part 2, we dig into:What “always bottom up” actually means (and what it doesn’t)Structural paradigm vs pathophysiology: why imaging often fails usWhy stress, fear, and emotions are usually modulators, not causesThreshold models: when trajectories may (and may not) be changeableThe case for neuroimmune mechanisms in chronic pain statesWhere diagnostics and biologics may take chronic pain care nextWhat role physios may play as case managers and guidesThis is the second half of a two-part series. Part 1 builds the framework. Part 2 challenges how we interpret evidence, scope, and clinical uncertainty—while staying anchored to what helps the patient in front of you.*********************************************************************📸 - Follow us on Instagram  -  https://www.instagram.com/modernpaincare/🐦 - Follow us on Twitter -  https://www.twitter.com/modernpaincare/🎙️ - Listen to our Podcast - https://www.modernpaincare.com____________________________________Modern Pain Care is a company dedicated to spreading evidence-based and person-centered information about pain, prevention, and overall fitness and wellness

Part 2 goes from definitions to implications. Bottom-up pain does not mean “it’s in the tissues.” This episode is a recording of a live interview with pain researcher and clinician Asaf Weissman. If you haven’t watched Part 1, start there—we laid the foundation: why pain semantics matter, how mixed messages harm patients, and why “nothing is wrong with your body” is an overreach. In Part 2, we dig into: What “always bottom up” actually means (and what it doesn’t)Structural paradigm vs pathoph...

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Why Imaging Misses Chronic Pain: Structural vs Physiologic Thinking (Part 2)

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This episode was published on January 11, 2026.

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Part 2 goes from definitions to implications.Bottom-up pain does not mean “it’s in the tissues.”This episode is a recording of a live interview with pain researcher and clinician Asaf Weissman. If you haven’t watched Part 1, start there—we laid the...

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