Why Psychedelics May Outperform Antidepressants!

What this episode covers

Dr. Robin Carhart-Harris is a neuroscientist and professor of neurology and psychiatry at the University of California, San Francisco, where he leads the Psychedelics Division. He is internationally recognized for pioneering research on psychedelics, brain function, and mental health. His studies have revealed how substances like psilocybin and LSD can “reset” brain networks and offer therapeutic potential for conditions such as depression and anxiety. Dr. Carhart-Harris is a leading voice in the renaissance of psychedelic science, making groundbreaking neuroscience accessible to both scientific and public audiences.In our conversation we discuss:(00:00) Misunderstandings people have about psychedelics(02:27) Differentiating psychedelics from drugs like ketamine, MDMA(08:39) Why people group all drugs together(14:57) History of ancestral use of psychedelics(21:46) Visions or insights during dark retreat(23:17) Biohacks for psychedelic experiences without compounds(29:10) Natural vs synthetic psychedelics and effects(32:28) Albert Hoffman’s discovery of LSD(37:45) Findings from legal LSD human studies(45:55) Comparing SSRIs and psychedelics for depression(46:27) Clarification on psilocybin as treatment(48:49) Qualitative vs quantitative measures in trials(51:34) No difference between SSRIs and psychedelics?(54:21) Hesitations about psychedelics despite effectiveness(54:56) Why clinicians hesitate to provide both options(58:04) Downsides of SSRIs versus psychedelics(1:03:46) Dependency risk of SSRIs vs psychedelics(1:07:49) Personality traits suited for SSRIs vs psychedelics(1:12:54) Microdosing versus single high psychedelic doses(1:14:48) Placebo or real effects of microdosing(1:18:57) Brian Johnson’s blueprint and psychedelics(1:20:32) Psychedelics and potential longevity benefits(1:26:01) Key takeaway and misconception to forget(1:29:04) Where to follow for book updatesLearn more about Dr. Robin:https://en.wikipedia.org/wiki/Robin_Carhart-Harrishttps://profiles.ucsf.edu/robin.carhart-harris@CarhartharrislabWatch full episodes on: https://www.youtube.com/@seankimConnect on IG: https://instagram.com/heyseankim

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This episode is 1 hour and 30 minutes long.

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This episode was published on October 10, 2025.

What is this episode about?

Dr. Robin Carhart-Harris is a neuroscientist and professor of neurology and psychiatry at the University of California, San Francisco, where he leads the Psychedelics Division. He is internationally recognized for pioneering research on...

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