Why Strattera Works (or Fails) Depending on Your Liver

Why does Strattera (atomoxetine) give some people crippling anxiety while others get life-changing focus? This episode unpacks the pharmacology, from its selective norepinephrine action in the prefrontal cortex to the critical role of the CYP2D6 liver enzyme. We compare it head-to-head with bupropion for the ADHD-depression-fatigue triad and explain why your genetics—not just your willpower—determine whether this drug is a miracle or a nightmare.