Why Your Antidepressants Stopped Working (And What To Do Next) episode artwork

EPISODE · May 18, 2026 · 11 MIN

Why Your Antidepressants Stopped Working (And What To Do Next)

from Rewire & Thrive · host Dr. Dee Bonney

If you can come to central Indiana for treatment, and you want to see if you qualify for this therapy, please schedule a free consultation: https://consult.alphaomegawellness.co...Have you been on Lexapro, Zoloft, Prozac, Wellbutrin, or Effexor for years, only to realize they aren't working like they used to? You aren't crazy, and you aren't weak. It's a documented medical phenomenon called tachyphylaxis (or "antidepressant poop-out"), and it happens to about 30% of people on SSRIs.In this video, Dr. Dee Bonney explains exactly what SSRIs do inside your brain, why your brain adapts by downregulating receptors, and why simply increasing your dose often leads to a plateau of emotional numbing and some side effects.More importantly, Dr. Dee explains the alternative path: the glutamate system. Learn how treatments like IV ketamine therapy bypass the serotonin system entirely to trigger the release of BDNF (Brain-Derived Neurotrophic Factor) - the "Miracle-Gro" for your brain that physically regrows synaptic connections lost to chronic stress and depression.If you've been quietly carrying on at an SSRI plateau, this video is for you. It's about brain health, not mental health. It's mechanism over willpower.

Episode metadata supplied by the publisher feed · Published May 18, 2026

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If you can come to central Indiana for treatment, and you want to see if you qualify for this therapy, please schedule a free consultation: https://consult.alphaomegawellness.co... Have you been on Lexapro, Zoloft, Prozac, Wellbutrin, or Effexor for years, only to realize they aren't working like they used to? You aren't crazy, and you aren't weak. It's a documented medical phenomenon called tachyphylaxis (or "antidepressant poop-out"), and it happens to about 30% of people on SSRIs. In thi...

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Why Your Antidepressants Stopped Working (And What To Do Next)

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