Why Your Weight Loss Drug Stopped Working and What to Do About It episode artwork

EPISODE · Jun 8, 2026 · 20 MIN

Why Your Weight Loss Drug Stopped Working and What to Do About It

from The Habit Healers · host Laurie Marbas, MD, MBA

GLP-1 weight loss medications are evolving faster than most people can track, and a lot of what you’ve heard is already out of date. In this episode I give you the updated map: how Ozempic, Wegovy, Mounjaro, Zepbound, and the new triple agonist retatrutide actually differ, and why it matters for your results.Here’s what I want you to know. These drugs aren’t a willpower fix, they’re correcting the hormonal signals that drive hunger and metabolism, and each generation adds another dial. I walk through semaglutide, tirzepatide, and retatrutide in plain language, then tackle the question that frustrates so many patients: why the scale stops moving. The weight loss plateau isn’t your body becoming immune to the medication. It’s metabolic adaptation, and once you understand it, you have real options. We also cover the new higher-dose semaglutide, the oral GLP-1 pill, and the lifestyle habits, protein, strength training, fiber, and sleep, that amplify whatever your medication is doing.What you’ll learn:* How semaglutide, tirzepatide, and retatrutide differ in how they work* Why the GLP-1 weight loss plateau happens and what to do next* How to protect muscle with protein and strength training on a GLP-1* What the research shows about weight regain after coming off these drugs* New options: higher-dose semaglutide and the oral GLP-1 pillDr. Marbas Substack Article: https://drlauriemarbas.substack.com/p/why-your-weight-loss-drug-stoppedCheck out the Habit Healers Community: https://www.skool.com/habithealers/about Get full access to The Habit Healers at drlauriemarbas.substack.com/subscribe

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Why Your Weight Loss Drug Stopped Working and What to Do About It

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This episode was published on June 8, 2026.

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GLP-1 weight loss medications are evolving faster than most people can track, and a lot of what you’ve heard is already out of date. In this episode I give you the updated map: how Ozempic, Wegovy, Mounjaro, Zepbound, and the new triple agonist...

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