Will Gut Microbiome Transplants Lead to New Treatments for Ulcerative Colitis?

In this podcast episode, we explore the crucial role of the gut microbiome, a complex ecosystem within us composed primarily of bacteria that perform essential functions for our health. We discuss how the microbiome influences everything from nutrient absorption to immune response and how its imbalance leads to conditions like ulcerative colitis. Highlighting cutting-edge research, we delve into the potential of fecal transplants and dietary changes to restore gut health. This fascinating journey into our internal universe underscores the importance of maintaining microbial diversity for overall well-being and paves the way for innovative treatments in gastrointestinal health.Participate in clinical research!www.ENCOREdocs.comShare with a friend. Rate, Review, and Subscribe to the ENCORE Research Group podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence podcast. www.MedEvidence.comThank you for listening!References:Bengmark, S. (1998). Ecological control of the gastrointestinal tract. The role of probiotic flora. Gut, 42(1), 2-7. https://doi.org/10.1136/gut.42.1.2Fan, Y., & Pedersen, O. (2021). Gut microbiota in human metabolic health and disease. Nature Reviews Microbiology, 19(1), 55-71. https://doi.org/10.1038/s41579-020-0433-9Gomaa, E. Z. (2020). Human gut microbiota/microbiome in health and diseases: a review. Antonie Van Leeuwenhoek, 113(12), 2019-2040. https://link.springer.com/article/10.1007/s10482-020-01474-7LeBlanc, J. F., Segal, J. P., de Campos Braz, L. M., & Hart, A. L. (2021). The microbiome as a therapy in pouchitis and ulcerative colitis. Nutrients, 13(6), 1780. https://doi.org/10.3390/nu13061780Sender, R., Fuchs, S., & Milo, R. (2016). Revised estimates for the number of human and bacteria cells in the body. PLoS biology, 14(8), e1002533. https://doi.org/10.1371/journal.pbio.1002533Świrkosz, G., Szczygieł, A., Logoń, K., Wrześniewska, M., & Gomułka, K. (2023). The Role of the Microbiome in the Pathogenesis and Treatment of Ulcerative Colitis—A Literature Review. Biomedicines, 11(12), 3144. https://doi.org/10.3390/biomedicines11123144Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014). The role of short-chain fatty acids in health and disease. Advances in immunology, 121, 91-119. https://doi.org/10.1016/b978-0-12-800100-4.00003-9The Human Microbiome Project Consortium. (2021). Structure, function and diversity of the healthy human microbiome. Nature 486, 207–214. https://www.nature.com/articles/nature11234 Thursby, E., & Juge, N. (2017). Introduction to the human gut microbiota. Biochemical journal, 474(11), 1823-1836. https://portlandpress.com/biochemj/article/474/11/1823/49429Xiong, R. G., Zhou, D. D., Wu, S. X., Huang, S. Y., Saimaiti, A., Yang, Z. J., ... & Li, H. B. (2022). Health benefits and side effects of short-chain fatty acids. Foods, 11(18), 2863. https://doi.org/10.3390%2Ffoods11182863Young, V. B., & Schmidt, T. M. (2008). Overview of the gastrointestinal microbiota. Advances in experimental medicine and biology, 635, 29–40. https://doi.org/10.1007/978-0-387-09550-9_3Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.comThank you for listening!