World J Gastroenterol . 2025 Aug Positioning and sequencing of advanced therapies in inflammatory bowel disease: A guide for clinical practice

This academic review explores the modern landscape of inflammatory bowel disease treatment, which has evolved from a limited selection of drugs to a diverse array of advanced biological and molecular therapies. As the number of available medications increases, clinicians face the growing challenge of optimizing the sequence and positioning of these treatments to manage complex patient cases effectively. Because precise biomarkers are not yet available to guide these choices, the text highlights how doctors must personalize care by balancing clinical factors like disease severity, safety profiles, and patient comorbidities. Ultimately, the source serves as a practical framework for navigating these difficult therapeutic decisions to improve long-term outcomes for those suffering from chronic intestinal inflammation.