World J Gastroenterol . 2025 May 28 Metabolic dysfunction-associated steatotic liver disease: A story of muscle and mass

This text explores the intricate bidirectional relationship between metabolic liver disease and skeletal muscle health, illustrating how physical decline both mirrors and worsens hepatic damage. The author identifies sarcopenia and myosteatosis—the loss of muscle mass and the infiltration of fat into muscle tissue—as critical factors that drive insulin resistance and systemic inflammation, ultimately accelerating the progression toward liver fibrosis. By examining how impaired muscle metabolism and poor circulation limit a patient's physical capacity, the source highlights a vicious cycle of metabolic dysfunction that increases the risk of mortality. Ultimately, the article advocates for integrated management strategies, such as specialized exercise and nutritional support, to break this cycle and improve patient survival.