YOU MUST WATCH! Healing Without Destruction: PEF Ablation for Advanced Cancer with Dr. Justin Thomas

In this episode, we explore one of the most exciting emerging frontiers in cancer treatment: Pulsed Electric Field (PEF) ablation—a non-thermal technology that uses short bursts of high-voltage energy to disrupt cancer cells while preserving surrounding healthy tissue. Unlike traditional ablation methods that rely on heat or freezing, PEF works by creating microscopic pores in cancer cell membranes, leading to cell death without damaging critical structures like blood vessels, airways, or connective tissue. This unique mechanism opens the door to treating tumors that were previously considered too risky—or impossible—to ablate. Our discussion focuses on how PEF ablation is being delivered through robotic bronchoscopy, allowing physicians to reach lung tumors with unprecedented precision. This approach is especially relevant for patients with advanced or oligometastatic cancer, where local control may play a critical role in improving quality of life—and potentially survival. Emerging clinical evidence suggests that PEF may do more than just destroy tumors locally. Early data indicate it may also stimulate the immune system, creating a systemic anti-cancer response that could complement immunotherapy and other systemic treatments. This has raised important questions about whether local therapies like PEF could help shift outcomes even in advanced-stage disease. We also discuss the ongoing AFFINITY Trial, a pivotal clinical study evaluating the safety and effectiveness of pulsed electric field ablation in lung tumors. This trial represents a major step toward understanding how this technology may fit into the future standard of care. Learn more about the AFFINITY Trial: https://www.mdpi.com/2072-6694/17/21/3495 Learn more about the Propensity Matched Trial from Bill Moore at NYU in patients with Stage IV Recalcitrant Lung Cancer: https://www.lungcancerjournal.info/action/showPdf?pii=S0169-5002%2825%2900467-2 Whether you are a patient, caregiver, or clinician, this episode offers a clear and hopeful look at how energy-based, precision medicine is reshaping what’s possible in cancer care—moving beyond palliation toward real opportunity. Key Topics Covered: What pulsed electric field ablation is—and how it works How robotic bronchoscopy enables precise delivery in the lung Why non-thermal ablation matters for safety and outcomes The potential immune and survival implications of PEF Ongoing research and the AFFINITY clinical trial 760-834-3564Transforming your health is more fun with friends! Join Chef AJ’s Exclusive Plant-Based Community. Become part of the inner circle and start simplifying plant-based living - with easy recipes and expert health guidance. Find out more by visiting: https://community.chefaj.com/ ORDER MY NEW BOOK SWEET INDULGENCE!!! https://www.amazon.com/Chef-AJs-Sweet-Indulgence-Guilt-Free/dp/1570674248 or https://www.barnesandnoble.com/w/book/1144514092?ean=9781570674242 GET MY FREE INSTANT POT COOKBOOK: https://www.chefaj.com/instant-pot-download MY BEST SELLING WEIGHT LOSS BOOK: https://www.amazon.com/dp/1570674086?tag=onamzchefajsh-20&linkCode=ssc&creativeASIN=1570674086&asc_item-id=amzn1.ideas.1GNPDCAG4A86S Disclaimer: This podcast does not provide medical advice. The content of this podcast is provided for informational or educational purposes only. It is not intended to be a substitute for informed medical advice or care. You should not use this information to diagnose or treat any health issue without consulting your doctor. Always seek medical advice before making any lifestyle changes.