EPISODE · May 9, 2026 · 22 MIN
Zombie Cells in the Wound: How Senescent Fibroblasts Sabotage Diabetic Ulcers
from Diabetic Foot Files · host Diabetic Foot Files
Dr. G examines how normal fibroblasts drive tissue repair and how, in diabetic foot ulcers, they can become senescent “zombie” cells that stop dividing, secrete inflammatory SASP factors, and degrade the wound environment. The episode covers triggers (hyperglycemia, oxidative stress, ischemia, infection), clinical signs and biomarkers of senescence, the vicious cycle with biofilm, and emerging approaches—including senolytics, targeted dressings, and debridement—to reduce senescent burden and improve healing.
What this episode covers
Dr. G examines how normal fibroblasts drive tissue repair and how, in diabetic foot ulcers, they can become senescent “zombie” cells that stop dividing, secrete inflammatory SASP factors, and degrade the wound environment.The episode covers triggers (hyperglycemia, oxidative stress, ischemia, infection), clinical signs and biomarkers of senescence, the vicious cycle with biofilm, and emerging approaches—including senolytics, targeted dressings, and debridement—to reduce senescent burden and improve healing.
NOW PLAYING
Zombie Cells in the Wound: How Senescent Fibroblasts Sabotage Diabetic Ulcers
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
No similar podcasts found.