PODCAST · science
biosights
by The Rockefeller University Press
biosights is a series of life science videos highlighting original scientific research published in The Journal of Cell Biology. The shows feature original video data and interviews with the scientists who performed the work.
Episodes
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biosights: June 4, 2018
Lymphatic exosomes help dendritic cells find their way Under inflammatory conditions, antigen-presenting dendritic cells are attracted to lymphatic vessels by chemokines secreted from the basolateral surface of lymphatic endothelial cells. Brown et al. reveal that lymphatic endothelial cells also...
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biosights: May 7, 2018
BBSome trains provide receptors a passage out of cilia Many G protein–coupled receptors accumulate in the membrane of primary cilia and then exit this sensory organelle when their signaling pathway is activated. Ye et al. reveal that the BBSome complex facilitates the signal-dependent exit of…
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biosights: April 2, 2018
Dia1-dependent adhesions help epithelia branch out The actin cytoskeleton and its regulators play key roles in the maturation and stabilization of focal adhesions but how adhesion maturation affects tissue morphogenesis is largely unknown. Fessenden et al. reveal that the actin-nucleating formin...
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biosights: March 5, 2018
The nucleus comes through in the clutch In addition to its roles in DNA replication and gene expression, the nucleus has an important physical impact on cellular behavior. Graham et al. reveal that, although the nucleus is dispensable for cell polarization and migration on 2D surfaces, it is...
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biosights: February 5, 2018
Cytotoxic T cells use Flower power In order to efficiently kill multiple target cells, cytotoxic T lymphocytes must endocytose and recycle cytotoxic granule membrane components from the immunological synapse. Chang et al. reveal that a protein called Flower facilitates granule endocytosis in a...
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biosights: January 2, 2018
Ring out your dead: MRCKα cleavage triggers epithelial extrusion Dying epithelial cells are extruded from the tissue by a basal actomyosin ring formed in neighboring, healthy cells. Gagliardi et al. reveal that epithelial extrusion is also driven by actin rearrangements in the apoptotic cell…
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biosights: December 4, 2017
Adult neuroblasts DOCK into position In the postnatal/adult brain, interneuron precursors, or neuroblasts, migrate along the rostral migratory stream by undergoing cycles of leading process extension followed by somal translocation. Nakamuta et al. reveal that the Rac/Cdc42 guanine nucleotide...
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biosights: November 6, 2017
Cancer-associated fibroblasts lay the tracks for directional migration Cancer-associated fibroblasts, or CAFs, regulate tumor progression by secreting chemokines and remodeling the extracellular matrix. Erdogan et al. reveal that the CAF-dependent alignment of fibronectin promotes directional...
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biosights: October 2, 2017
Drp1 cuts off mitophagy Misfolded mitochondrial proteins can be eliminated by Parkin-dependent mitophagy but how this process selectively removes damaged mitochondrial regions is unclear. Burman et al. reveal that protein aggregates in the mitochondrial matrix trigger a local accumulation of…
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biosights: September 4, 2017
Synaptic activity shifts dendritic lysosomes Invading pathogens or other toxic agents can trigger the assembly of the inflammasome adaptor ASC into large, intracellular specks that activate caspase-1 to initiate a proinflammatory cell death called pyroptosis. Kuri et al. follow the dynamics of…
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biosights: August 7, 2017
Synaptic activity shifts dendritic lysosomes Lysosomes are known to exist in both the cell body and axon of neurons, but whether they also localize to dendrites is unclear. Goo et al. reveal that lysosomes do exist in dendrites and dendritic spines, and that their trafficking in this region of...
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biosights: July 3, 2017
Myosins team up to help secretory granules integrate Actomyosin contractility drives a variety of membrane remodeling events, including the integration of secretory granules into the apical plasma membrane after exocytosis. By visualizing granule integration in the salivary glands of live mice,...
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biosights: June 5, 2017
Broken chromosomes stay on the safe side in mitosis Unrepaired DNA double strand breaks can generate chromosome fragments that lack centromeres but, surprisingly, these acentric chromosomes can nevertheless segregate to spindle poles during mitosis. Karg et al. reveal that, in Drosophila...
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biosights: May 1, 2017
The cell cortex makes use of plastin's connections Cortical actomyosin contractility regulates a variety of morphogenetic processes at both the cellular and tissue-based levels. Ding et al. reveal that, in the Caenorhabditis elegans zygote, the actin cross-linking protein plastin optimizes...
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biosights: April 3, 2017
How Chlamydia help mitochondria keep it together The obligate intracellular bacterium Chlamydia trachomatis must keep its host cell alive, even though it produces reactive oxygen species that expose the host cell to oxidative stress. Chowdhury et al. reveal that Chlamydia mitigates this oxidative...
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biosights: March 6, 2017
Actin isoforms divide their responsibilities in motoneurons Actin dynamics are crucial for axon growth and branching, but most studies have only focused on the role of β-actin. Moradi et al. reveal that α-, β-, and γ-actin have different functions in motoneuron axons; locally translated α-actin...
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biosights: February 6, 2017
Localizing mTORC2 activity The mTORC2 complex regulates cell growth and proliferation by phosphorylating the protein kinase Akt, but where in the cell mTORC2 is active, and how growth factors direct its activity towards Akt, remains unclear. Ebner et al. use a novel reporter to show that…
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biosights: January 2, 2017
Tumor cells feel the pressure after protease inhibition Primary fibroblasts use a high pressure, "nuclear piston" mode of migration to move through highly cross-linked 3D extracellular matrices. Petrie et al. reveal that tumor cells with high levels of matrix metalloproteinase activity generally...
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biosights: December 19, 2016
How NK cells avoid collateral damage Before secreting their lytic granules to kill transformed or virally infected cells, natural killer cells converge these lysosome-related organelles around the microtubule-organizing center. Hsu et al. reveal that, by promoting the granules' directed secretion...
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biosights: November 21, 2016
Formin' arcs at the immunological synapse When a T cell encounters an antigen-presenting cell, it dramatically reorganizes its cytoskeleton to form a specialized contact site called the immunological synapse. Murugesan et al. use superresolution microscopy to reveal that the medial region of the...
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biosights: October 24, 2016
Retinal ganglion cells have a backup plan Retinal ganglion cells (RGCs) are born at the apical side of the retinal neuroepithelium before they translocate to the basal side and send out axons to form the optic nerve. Icha et al. reveal that, in the zebrafish retina, RGC translocation is expedited...
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biosights: September 26, 2016
An iron hand controls endosome-mitochondria contacts In erythroid cells, endocytosed iron is directly transferred into mitochondria at dynamic endosome-mitochondria contacts. Das et al. reveal that this process also occurs in epithelial cells, and that the motility of endosomes, and the duration…
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biosights: August 29, 2016
Septins step in to promote macropinosome fusion After they are formed by the closure of membrane ruffles, macropinosomes mature by fusing with each other and with endosomes, before eventually delivering their fluid phase cargo to lysosomes. Dolat and Spiliotis reveal that septin filaments promote...
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biosights: August 1, 2016
The midbody enables ciliogenesis Fibroblasts initiate ciliogenesis inside the cell, but polarized epithelial cells form a primary cilium at the apical cell surface through a mechanism that is largely uncharacterized. Bernabé-Rubio et al. reveal that, in polarized MDCK cells, a remnant of the...
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biosights: July 4, 2016
Mobilizing mitochondria aids axon regeneration In mature neurons, the axonal transport of mitochondria is suppressed by the expression of the mitochondrial anchoring protein syntaphilin. Zhou et al. reveal that enhancing mitochondrial transport in mature neurons rescues energy deficits and...
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biosights: June 6, 2016
Neural crest cells stay within versican's confines Spatial confinement enhances collective cell migration in vitro, but whether it promotes collective migration in vivo is unclear. Szabó et al. reveal that the extracellular matrix protein versican confines neural crest cells to enhance their...
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biosights: May 9, 2016
Surf's uptake! Exosomes ride filopodia into cells Exosomes are small, extracellular vesicles that transfer lipid, protein, and RNA cargoes between cells, but relatively little is known about how they are taken up and processed by their target cells. Heusermann et al. reveal that exosomes "surf"...
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biosights: April 11, 2016
Sac1 works its contacts The plasma membrane phosphoinositide PI(4,5)P2 is derived from PI(4)P, whose levels are controlled by the essential lipid phosphatase Sac1. Sac1 is an integral ER membrane protein, but Dickson et al. reveal that it localizes to dynamic ER–plasma membrane contact sites to...
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biosights: March 14, 2016
Fat2 whips fly eggs into shape During Drosophila oogenesis, the collective migration of egg chamber follicle cells drives the chambers' rotation and elongation. Squarr et al. reveal that the atypical cadherin Fat2 recruits the WAVE regulatory complex to tricellular junctions to induce the…
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biosights: February 15, 2016
Chipping away at the problems of cardiac stem cell therapy Though stem cells transplanted into heart attack patients can develop into cardiomyocytes and integrate with undamaged host tissue, preclinical studies and clinical trials have only shown limited improvements in cardiac function. Using a...
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biosights: January 18, 2016
P-cadherin provides the driving force for collective cell migration Collective cell migration is an important process in normal development, wound repair, and tumor metastasis. Plutoni et al. reveal that the cell adhesion molecule P-cadherin promotes collective cell migration via the small GTPase...
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biosights: December 21, 2015
How catastrophes help oocytes avoid disaster During meiosis, oocytes must attach homologous chromosomes to opposite spindle poles, but the cells take several hours to assemble a bipolar spindle. Gluszek et al. reveal that, in Drosophila oocytes, the microtubule catastrophe–promoting protein…
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biosights: November 23, 2015
Cells migrate on the crest of a wave Cells move through complex 3D environments in vivo, but studying 3D modes of migration in vitro remains a major challenge. Guetta-Terrier et al. examine the movement of cells along suspended nanofibers that mimic 3D fibrillar matrices and find that their...
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biosights: October 26, 2015
CLIP-170 tips its hand in viral transport After entering a cell, many viruses move toward the nucleus by binding to the microtubule-based motor protein dynein. Jovasevic et al. reveal, however, that herpes simplex virus must first associate with the plus ends of microtubules in a process that...
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biosights: September 28, 2015
Maintaining the link between spindle and furrow position The cytokinetic cleavage furrow must be carefully aligned with the spindle midzone during asymmetric cell division. Pacquelet et al. discover a pathway that maintains the connection between spindle and furrow position in one-cell C. elegans...
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biosights: August 31, 2015
Pushing the envelope on spindle assembly During mitosis, numerous proteins accumulate around the mitotic spindle to help it assemble and segregate sister chromatids correctly. Schweizer et al. reveal that a membranous spindle envelope facilitates the accumulation of these proteins by excluding...
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biosights: August 3, 2015
Endocytosis brings closure to epithelial wounds Epithelial cells bordering a wound respond by forming two types of actin-based structure: dynamic membrane protrusions that help the cells crawl into the wound and/or seal it and an actomyosin cable that encircles the wound and closes it like a…
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biosights: July 6, 2015
Interphase centrosomes flare up Centrosomes undergo dramatic changes in size and structure during the rapid cell cycles of early Drosophila embryos. Lerit et al. reveal that a scaffold formed by the proteins centrosomin and PLP is required to maintain the activity of interphase centrosomes, which...
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biosights: June 8, 2015
Melanosomal cargoes BLOC'd off from alternate routes The BLOC-2 complex contains three subunits encoded by genes mutated in Hermansky-Pudlak syndrome, a disease caused by defects in the trafficking pathways that form melanosomes and other lysosome-related organelles. Dennis et al. reveal that the...
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biosights: May 11, 2015
Formin' actin at adherens junctions Actin assembly promotes the formation of intercellular adherens junctions, but the role of actin-nucleating formin proteins in this process remains unclear. Grikscheit et al. reveal that, in breast epithelial cells cultured in 3D, the formin FMNL2 stimulates...
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biosights: April 13, 2015
A motif that helps myosin II-B lead from behind Myosin II-A and myosin II-B play distinct roles in establishing the front–back polarity of migrating mesenchymal cells. Juanes-Garcia et al. identify a short, serine-rich motif in the non-helical tail domain of myosin II-B that enables this isoform…
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biosights: March 16, 2015
PAPC separates tissues at a Snail's pace Brachet's cleft separates the ectoderm and mesoderm of early Xenopus and zebrafish embryos. Luu et al. reveal that, in conjunction with the transcription factor Snail1, the protocadherin PAPC promotes tissue separation by down-regulating planar cell…
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biosights: February 16, 2015
Filopodia point the way for haptotaxis Migrating fibroblasts maintain or change their direction by branching off new lamellipodia from existing protrusions at the cell's leading edge. Johnson et al. reveal that filopodial protrusions initiate and orient these lamellipodia, helping fibroblasts...
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biosights: January 19, 2015
Tubulin transport pumps up cilia The assembly of cilia and flagella requires the delivery of large amounts of tubulin to the growing ends of the organelles' microtubules. Craft et al. reveal that tubulin loading onto intraflagellar transport particles is specifically upregulated in growing cilia....
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biosights: December 22, 2014
Osmotic gradient is just the tonic for wounded epithelia Rapid wound repair is generally thought to be initiated by intrinsic cues, such as changes in the structure or mechanics of damaged tissues. Gault et al. reveal that an extrinsic signal — the osmolarity of the external environment — can...
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biosights: November 24, 2014
Dynein helps centrioles stick together Dynein has numerous functions in mitosis, but the function of the motor complex's light intermediate chains is poorly understood. Jones et al. reveal that dynein's light intermediate chains are required to maintain centrosome integrity during mitosis,...
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biosights: October 27, 2014
Cdc42 prompts a change of heart The apical surfaces of polarized epithelia are covered by short, actin-rich protrusions called microvilli, but what happens to these structures when cells detach from a monolayer during development or disease is unclear. Klingner et al. reveal that non-confluent...
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biosights: September 29, 2014
Cdc42 prompts a change of heart The Drosophila heart is a simple tubular structure with a central lumen. Vogler et al. reveal that the small GTPase Cdc42 and actin-nucleating formin proteins promote lumen formation by regulating the dynamics of non-muscle myosin in cardioblasts during heart...
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biosights: September 1, 2014
Deploying exosomes in a battle of the sexes The paired accessory glands of male Drosophila secrete multiple signaling factors into the seminal fluid that promote reproductive success by altering the recipient female's physiology and behavior. This biosights episode presents the paper by Corrigan…
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biosights: August 4, 2014
Rok keeps its finger on the pulse of apical constriction Early in Drosophila embryogenesis, contractile pulses of myosin assembly and disassembly constrict the apical domains of a group of epithelial cells to drive their invagination into a ventral furrow. Vasquez et al. reveal that Rho kinase…
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ABOUT THIS SHOW
biosights is a series of life science videos highlighting original scientific research published in The Journal of Cell Biology. The shows feature original video data and interviews with the scientists who performed the work.
HOSTED BY
The Rockefeller University Press
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How many episodes does biosights have?
biosights currently has 119 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is biosights about?
biosights is a series of life science videos highlighting original scientific research published in The Journal of Cell Biology. The shows feature original video data and interviews with the scientists who performed the work.
How often does biosights release new episodes?
biosights publishes regularly with 119 episodes available. Check the episode list for the typical release schedule.
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You can listen to biosights on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts biosights?
biosights is created and hosted by The Rockefeller University Press.
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